Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Tert-Butanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butanol SCHEMBL217036 | 0.95 | — | — | |
| Tert-Butanol SCHEMBL17763313 | 0.95 | ALDH1A1 (0.60) | ALDH1A1LMNACYP2C19MAPK1TSHR | |
| Tert-Butanol SCHEMBL28273931 | 0.91 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19MAPK1TSHR | |
| Tert-Butanol SCHEMBL1134592 | 0.91 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19MAPK1TSHR | |
| Tert-Butanol SCHEMBL8647334 | 0.91 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19MAPK1TSHR | |
| Tert-Butanol SCHEMBL894082 | 0.91 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19MAPK1TSHR | |
| Tert-Butanol SCHEMBL3456548 | 0.91 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19MAPK1TSHR | |
| Isopropyl Alcohol SCHEMBL29068742 | 0.86 | — | — | |
| Isopropyl Alcohol SCHEMBL22587395 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19MAPK1TSHR | |
| Tert-Butanol SCHEMBL5867069 | 0.81 | TSHR (0.43) | ALDH1A1LMNACYP2C19MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110981975-A | Method for increasing viscosity of hydroxyethyl cellulose | 泸州北方纤维素有限公司 | 2020-04-10 | — | — | CN | disclosed |
| CN-105218314-B | The method that double extractive distillation columns combine separating isopropanol, the tert-butyl alcohol and water mixed solution | 南京师范大学 | 2017-03-08 | — | — | CN | disclosed |
| CN-105218314-A | Two extractive distillation column is in conjunction with the method for separating isopropanol, the trimethyl carbinol and water mixed solution | UNIV NANJING NORMAL | 2016-01-06 | — | — | CN | disclosed |
| CN-104829739-A | Preparation method of low-viscosity cationic guar gum powder | SHANDONG GP NATURAL PRODUCTS CO LTD | 2015-08-12 | — | — | CN | disclosed |