Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 7/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | IFNAR1 | P17181 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286439 | 0.79 | TP53 (0.36) | MAPTTAAR1 | |
| SCHEMBL17697662 | 0.77 | CALM1 (0.42) | KDM4ECYP3A4MAPTTAAR1 | |
| SCHEMBL7311782 | 0.75 | ALDH1A1 (0.36) | TAAR1 | |
| SCHEMBL28033340 | 0.75 | TAAR1 (0.45) | CYP3A4TAAR1 | |
| SCHEMBL27651823 | 0.72 | KDM4E (0.37) | KDM4ECYP3A4MAPTPRMT6IFNAR1 | |
| SCHEMBL379055 | 0.72 | ALDH1A1 (0.47) | CYP3A4MAPTATMTAAR1SLC6A4 | |
| SCHEMBL21177097 | 0.71 | KDM4E (0.35) | KDM4ECYP3A4MAPTPRMT6IFNAR1 | |
| SCHEMBL15756039 | 0.70 | GABRA1 (0.35) | — | |
| SCHEMBL27472235 | 0.70 | — | — | |
| SCHEMBL7307513 | 0.68 | CYP2D6 (0.35) | KDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124575-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |