SCHEMBL28037210

SCHEMBL28037210

Nc1ccc(C=C(c2ccccc2)c2ccc(Br)cc2)c(-c2ccc(Br)cc2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPRS1 P07814 1/20 0.39
HDAC2 Q92769 1/20 0.36
GRM2 Q14416 1/20 0.36
CYP1A1 P04798 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP1B1 Q16678 1/20 0.35
ALDH1A1 P00352 2/20 0.34
MAPK1 P28482 2/20 0.34
MAPT P10636 2/20 0.34
POLB P06746 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
F10 P00742 1/20 0.33
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
ACHE P22303 1/20 0.33
TP53 P04637 1/20 0.33
ATM Q13315 1/20 0.33
TLR9 Q9NR96 1/20 0.33
ALOX15 P16050 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1539828 0.90 CYP3A4 (0.41) ALDH1A1MAPTPTGDR2KMT2AMEN1
SCHEMBL4246291 0.90 KMT2A (0.40) ALDH1A1MAPTPTGDR2KMT2AMEN1
SCHEMBL27913794 0.88 KMT2A (0.41) ALDH1A1MAPK1MAPTPTGDR2KMT2A
SCHEMBL986595 0.81 ALDH1A1 (0.42) HDAC2GRM2CYP1B1ALDH1A1MAPK1
SCHEMBL6013880 0.80 NPC1 (0.37) ALDH1A1MAPTKMT2AMEN1ACHE
SCHEMBL27792351 0.79 BCAT2 (0.39) ALDH1A1MAPK1MAPTPTGDR2KMT2A
SCHEMBL28652203 0.78 MAPK1 (0.39) HDAC2GRM2ALDH1A1MAPK1MAPT
SCHEMBL19832033 0.76 ALDH1A1 (0.43) HDAC2GRM2CYP1A1CYP1A2CYP1B1
SCHEMBL28005325 0.76 ADORA2A (0.36) ALDH1A1MAPK1MAPTPOLBPTGDR2
SCHEMBL22125988 0.75 MMP9 (0.35) ALDH1A1MAPK1MAPTPTGDR2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103204996-B Organic electroluminescence device MERCK PATENT GMBH (DE) 2015-12-09 CN disclosed