Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR known ✓ | P25105 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28041356 | 0.90 | RXRA (0.33) | KIF11RXRARXRB | |
| SCHEMBL17386832 | 0.82 | KIF11 (0.40) | KIF11RXRARXRBPTAFRPTPN5 | |
| SCHEMBL28041345 | 0.80 | KIF11 (0.38) | KIF11RXRARXRBPTAFRPTPN5 | |
| Hydrochloric Acid SCHEMBL7058361 | 0.79 | HTR1A (0.37) | — | |
| Hydrochloric Acid SCHEMBL4089006 | 0.79 | CHRNB2 (0.35) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17387078 | 0.78 | KIF11 (0.38) | KIF11RXRARXRBPTPN5HDAC4 | |
| SCHEMBL17415931 | 0.77 | KIF11 (0.36) | KIF11RXRARXRBPTAFRPTPN5 | |
| SCHEMBL17414967 | 0.76 | KIF11 (0.35) | KIF11RXRARXRBPTAFRPTPN5 | |
| Fluoride Ion SCHEMBL5183964 | 0.76 | CHRNB2 (0.35) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| Bromide SCHEMBL27477694 | 0.76 | CHRNB2 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105026408-A | Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer | JAPAN POLYETHYLENE CORP | 2015-11-04 | — | — | CN | disclosed |