Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.49 |
| ▸ | C5AR1 | P21730 | 5/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12524630 | 0.80 | REN (0.50) | RENC5AR1ADRA1DADRA1AADRA1B | |
| SCHEMBL6943581 | 0.76 | REN (0.47) | RENC5AR1ADRA1DADRA1AADRA1B | |
| SCHEMBL19526619 | 0.76 | REN (0.59) | RENADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL28785298 | 0.76 | MTNR1A (0.44) | RENC5AR1KDM4E | |
| SCHEMBL682767 | 0.76 | MAPT (0.49) | C5AR1KDM4ETDP1F2F10 | |
| SCHEMBL27795807 | 0.75 | HTR1A (0.61) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL18715976 | 0.75 | L3MBTL1 (0.52) | C5AR1ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL13433963 | 0.75 | L3MBTL1 (0.52) | C5AR1ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL20577097 | 0.74 | SIGMAR1 (0.47) | RENADRA1DADRA1AADRA1B | |
| SCHEMBL21042791 | 0.74 | SLC6A4 (0.53) | ADRA1DADRA1AADRA1BHTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103562191-B | Nitrogen-containing saturated heterocyclic compound | SHANGHAI PHARMACEUTICALS HOLDING CO.,LTD. (CN) | 2016-03-30 | — | — | CN | disclosed |