Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12881525 | 0.78 | RAB9A (0.56) | MAPTHDAC8HDAC6HDAC2RAB9A | |
| SCHEMBL1396292 | 0.76 | MAPT (0.45) | MAPTLMNAHSD17B10GAARAB9A | |
| SCHEMBL1147718 | 0.74 | — | — | |
| SCHEMBL28275487 | 0.73 | KMT2A (0.36) | MAPTLMNAHSD17B10RAB9ANPC1 | |
| SCHEMBL27878947 | 0.72 | L3MBTL1 (0.37) | MAPTLMNAHSD17B10RAB9ANPC1 | |
| SCHEMBL9852009 | 0.68 | BRD4 (0.44) | MAPTLMNABRD4BRD2BRD3 | |
| SCHEMBL13469162 | 0.67 | IDH1 (0.70) | MAPTLMNABRD4BRD2BRD3 | |
| SCHEMBL30065638 | 0.66 | LMNA (0.42) | MAPTLMNABRD4BRD2BRD3 | |
| SCHEMBL30147703 | 0.64 | KDM4E (0.41) | MAPTLMNABRD4BRD2BRD3 | |
| SCHEMBL13088423 | 0.64 | LMNA (0.40) | MAPTLMNAHSD17B10HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130887-A | Regorafenib preparation method | JIANGSU ZHONGBANG PHARMACEUTICAL CO LTD | 2015-12-09 | — | — | CN | disclosed |