Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10063720 | 0.90 | POLB (0.46) | PARP10POLBTDP1TSHRKMT2A | |
| SCHEMBL13763456 | 0.83 | LMNA (0.53) | PARP10POLBTDP1TSHRKMT2A | |
| SCHEMBL9658504 | 0.83 | TAS1R3 (0.53) | PARP10ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11662636 | 0.83 | PARP10 (0.38) | CYP19A1PARP10POLBTDP1TSHR | |
| SCHEMBL6836501 | 0.82 | PARP10 (0.66) | PARP10POLBKMT2AGLAALDH1A1 | |
| SCHEMBL4763620 | 0.81 | LDHA (0.52) | PARP10POLBTDP1TSHRKMT2A | |
| SCHEMBL28492939 | 0.81 | CYP1A2 (0.46) | POLBTDP1TSHRKMT2AMAPK1 | |
| SCHEMBL316898 | 0.81 | MTNR1A (0.50) | KMT2AALDH1A1CYP3A4TP53CYP1A2 | |
| SCHEMBL3838993 | 0.80 | ALDH1A1 (0.40) | CYP19A1PARP10POLBTDP1TSHR | |
| SCHEMBL2881391 | 0.80 | TDP1 (0.52) | PARP10POLBTDP1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105102456-B | Azaquinazoline inhibitors of atypical protein kinase C | 癌症研究技术有限公司 | 2017-11-14 | — | — | CN | disclosed |
| CN-105102456-A | Azaquinazoline inhibitors of atypical protein kinase C | IGNYTA INC | 2015-11-25 | — | — | CN | disclosed |