Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.58 |
| ▸ | MAOB | P27338 | 9/20 | 0.58 |
| ▸ | TGM2 | P21980 | 5/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.45 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.44 |
| ▸ | CASP2 | P42575 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444879 | 0.77 | TGM2 (0.55) | MAOAMAOBTGM2CES1CA12 | |
| SCHEMBL11081844 | 0.74 | MAOA (0.47) | MAOAMAOBTGM2CES1CA12 | |
| SCHEMBL2789935 | 0.74 | MAOA (1.00) | MAOAMAOBTGM2CES1CA12 | |
| SCHEMBL5330038 | 0.73 | TGM2 (0.53) | MAOAMAOBTGM2CES1CA12 | |
| SCHEMBL16111115 | 0.72 | CES1 (0.53) | MAOAMAOBTGM2CES1CA12 | |
| Isatin SCHEMBL28365971 | 0.72 | MAOA (0.95) | MAOAMAOBTGM2CES1ALDH1A1 | |
| SCHEMBL1767901 | 0.71 | TGM2 (0.50) | MAOAMAOBTGM2CES1CA12 | |
| SCHEMBL4967546 | 0.71 | ALDH1A1 (0.55) | MAOAMAOBTGM2CES1CA12 | |
| SCHEMBL9330149 | 0.70 | MAOA (0.58) | MAOAMAOBTGM2CES1CA12 | |
| Isatin SCHEMBL34016 | 0.69 | MAOA (1.00) | MAOAMAOBTGM2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102256983-B | Spirooxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-105218565-A | Spiral shell oxindole compounds and the purposes as therapeutical agent thereof | XENON PHARMACEUTICALS INC | 2016-01-06 | — | — | CN | disclosed |
| CN-105175433-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2015-12-23 | — | — | CN | disclosed |