Guanosine

Guanosine

SCHEMBL8429254

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=C[C@H](OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.55
NT5E P21589 1/20 0.54
KRAS P01116 5/20 0.51
IMPDH2 P12268 6/20 0.50
FUT5 Q11128 1/20 0.50
HPGD P15428 1/20 0.50
P2RY2 P41231 1/20 0.49
P2RY4 P51582 1/20 0.49
P2RY6 Q15077 1/20 0.49
HINT1 P49773 1/20 0.49
GSK3A P49840 2/20 0.47
RPS6KA3 P51812 2/20 0.47
MAPK14 Q16539 2/20 0.47
IMPDH1 P20839 2/20 0.47
DCPS Q96C86 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL4816737 1.00 TGM2 (0.55) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL3264840 1.00 TGM2 (0.55) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL1421810 0.93 TGM2 (0.55) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL28048641 0.92 TGM2 (0.57) TGM2NT5EKRASIMPDH2FUT5
SCHEMBL5061620 0.90 NT5E (0.60) TGM2NT5EKRASIMPDH2FUT5
SCHEMBL7571229 0.90 NT5E (0.60) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL7571212 0.89 NT5E (0.55) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL6027663 0.89 NT5E (0.55) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL6066347 0.87 NT5E (0.69) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL9827513 0.87 NT5E (0.69) TGM2NT5EKRASIMPDH2FUT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119120439-A UDP/GDP-glucose epimerase for catalytic synthesis of UDP/GDP-mannose 江南大学 2024-12-13 CN claimed
CN-119331845-A High Wen Tangji-resistant transferase mutant and preparation method and application thereof 中国石油大学(华东) 2025-01-21 CN disclosed
WO-2025009254-A1 METHOD FOR DETECTING PRESENCE OR ABSENCE OF SUGAR, SUGAR DERIVATIVE, OR NUCLEOTIDE SUGAR 株式会社島津製作所 2025-01-09 WO disclosed
CN-119120439-A UDP/GDP-glucose epimerase for catalytic synthesis of UDP/GDP-mannose 江南大学 2024-12-13 CN disclosed
CN-118240787-A Glycosyltransferase, sucrose synthase and application thereof in preparation of rebaudioside M 万华化学集团营养科技有限公司 2024-06-25 CN disclosed
CN-117050965-A Glycosyltransferase and application thereof in preparing rebaudioside M 万华化学集团股份有限公司 2023-11-14 CN disclosed
CN-112457355-B Sugar nucleotide separation and purification method 武汉糖智药业有限公司 2022-06-07 CN disclosed
CN-112457355-A Sugar nucleotide separation and purification method 武汉糖智药业有限公司 2021-03-09 CN disclosed
CN-111263636-A New application of dextran sulfate TX医生公司 2020-06-09 CN disclosed
CN-107245458-B Screening and application of high-resistance trehalose-producing saccharomyces cerevisiae strain 湖北大学 2019-12-24 CN disclosed
CN-105002202-B The method that the phosphoric acid of glucose 1 is prepared using starch as raw material 浙江大学 2018-02-23 CN disclosed
CN-107245458-A A kind of screening and application of resistance production trehalose Wine brewing yeast strain 湖北大学 2017-10-13 CN disclosed
US-5888777-A Process for the complete removal of protective groups on nucleoside diphosphate and triphosphate sugars with acetylesterase NOVARTIS AG (CH) 1999-03-30 US disclosed
EP-0801684-A1 PROCESS FOR THE COMPLETE REMOVAL OF PROTECTIVE GROUPS ON NUCLEOSIDE DIPHOSPHATE AND TRIPHOSPHATE SUGARS Novartis AG (CH) 1997-10-22 EP disclosed
WO-1996024683-A1 PROCESS FOR THE COMPLETE REMOVAL OF PROTECTIVE GROUPS ON NUCLEOSIDE DIPHOSPHATE AND TRIPHOSPHATE SUGARS NOVARTIS AG (CH) 1996-08-15 WO disclosed