Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 10/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | STAMBP | O95630 | 1/20 | 0.36 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897370 | 0.79 | HCAR2 (0.47) | LMNA | |
| SCHEMBL31700802 | 0.79 | HCAR2 (0.47) | LMNA | |
| SCHEMBL7588782 | 0.79 | RAB9A (0.36) | SMN1; SMN2 | |
| SCHEMBL3998717 | 0.77 | NNMT (0.47) | NNMTLMNASMN1; SMN2HPGDSRAF1 | |
| SCHEMBL17490781 | 0.76 | NOS3 (0.52) | NNMTLMNASMN1; SMN2HPGDSRAF1 | |
| SCHEMBL2219734 | 0.76 | NNMT (0.46) | NNMTLMNASMN1; SMN2HPGDSRAF1 | |
| SCHEMBL18348165 | 0.75 | SMN1; SMN2 (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL487571 | 0.75 | ATM (0.51) | LMNAPSMD14 | |
| SCHEMBL27753208 | 0.75 | MAPT (0.38) | NNMTLMNASMN1; SMN2 | |
| SCHEMBL13465582 | 0.74 | LMNA (0.42) | NNMTLMNASMN1; SMN2HPGDSRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443074-B | Heterocyclic amine derivative | HOFFMAN-LA ROCHE LTD. (CH) | 2016-04-13 | — | — | CN | disclosed |