Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505593 | 0.84 | MAPK1 (0.53) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL29104725 | 0.82 | KDM4E (0.53) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL335203 | 0.81 | ATM (0.55) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL27753208 | 0.81 | MAPT (0.38) | ATMKDM4EMAPK1L3MBTL1LMNA | |
| SCHEMBL24213965 | 0.81 | MAPK1 (0.46) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL31386800 | 0.81 | KDM4E (0.49) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL29779593 | 0.81 | MAPK1 (0.46) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL18339475 | 0.81 | MAPT (0.46) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL17111632 | 0.81 | KDM4E (0.49) | ATMKDM4EMAPK1L3MBTL1PSMD14 | |
| SCHEMBL19689562 | 0.81 | MAPK1 (0.46) | ATMKDM4EMAPK1L3MBTL1PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023025277-A1 | AROMATIC RING-CONTAINING BIOLOGICAL ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2023-03-02 | — | — | WO | disclosed |
| WO-2020247160-A1 | CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-12-10 | — | — | WO | disclosed |
| US-20200361939-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED. | 2020-11-19 | — | — | US | disclosed |
| EP-2049488-B1 | N'-CYANO-N-ALKYL HALIDE IMIDE AMIDE DERIVATIVES | BAYER IP GMBH (DE) | 2015-12-09 | — | — | EP | disclosed |
| CN-102321081-B | Preparation method of substituted enaminocarbonyl compound used as insecticide and intermediate | BAYER CROPSCIENCE AG | 2015-05-20 | — | — | CN | disclosed |
| EP-2004636-B1 | Substituted enaminocarbonyl compounds used as insecticides | BAYER IP GMBH (DE) | 2015-04-22 | — | — | EP | disclosed |
| US-20140113824-A1 | BICYCLIC (THIO)CARBONYLAMIDINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-04-24 | — | — | US | disclosed |
| EP-2707373-A1 | BICYCLIC (THIO)CARBONYLAMIDINES | Bayer Intellectual Property GmbH (DE) | 2014-03-19 | — | — | EP | disclosed |
| CN-101460502-B | Bicyclic enamino(thio)carbonyl compounds | BAYER CROPSCIENCE AG | 2013-07-17 | — | — | CN | disclosed |
| EP-2021344-B1 | BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2013-05-08 | — | — | EP | disclosed |
| US-20090247551-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2009-10-01 | — | — | US | disclosed |
| CN-101516848-A | N'-cyano-N-alkyl halide imide amide derivatives | BAYER CROPSCIENCE AG (DE) | 2009-08-26 | — | — | CN | disclosed |
| US-20090181947-A1 | BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2009-07-16 | — | — | US | disclosed |
| CN-101460502-A | Bicyclic enamino(thio)carbonyl compounds | BAYER CROPSCIENCE AG (DE) | 2009-06-17 | — | — | CN | disclosed |
| CN-101454316-A | Substituted enaminocarbonyl compounds for use as pesticides | BAYER CROPSCIENCE AG (DE) | 2009-06-10 | — | — | CN | disclosed |
| CN-101415682-A | Substituted enaminocarbonyl compounds | BAYER CROPSCIENCE AG (DE) | 2009-04-22 | — | — | CN | disclosed |
| EP-2021344-A1 | BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS | Bayer CropScience AG (DE) | 2009-02-11 | — | — | EP | disclosed |
| EP-2004636-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS USED AS INSECTICIDES | Bayer CropScience AG (DE) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007115647-A1 | BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007115646-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS USED AS INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247551-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | DDT, NPEPPS, L3MBTL4 | ATM 3542/4885KDM4E 613/4885MAPK1 3414/4885 |
| US-20090181947-A1 | BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS | TARS2, TBCA, DDT | ATM 3396/4885KDM4E 2019/4885MAPK1 3681/4885 |
| US-20140113824-A1 | BICYCLIC (THIO)CARBONYLAMIDINES | BROX, BOLA2; BOLA2B, CAT | ATM 3227/4885KDM4E 1905/4885MAPK1 3771/4885 |
| US-20200361939-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | SERPINA2, SERPINC1, SERPINA3 | ATM 1292/4885KDM4E 4764/4885MAPK1 948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.