Sugi Predict

Sugi Predict / Compounds / SCHEMBL4897370

SCHEMBL4897370

SCHEMBL4897370

Cc1cc(C(=O)O)cnc1Br

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HCAR2 Q8TDS4 4/20 0.47
▸ POLB P06746 1/20 0.47
▸ P4HA1 P13674 2/20 0.44
▸ P4HTM Q9NXG6 2/20 0.44
▸ MIF P14174 1/20 0.44
▸ KDM4E B2RXH2 5/20 0.42
▸ ALDH1A1 P00352 5/20 0.42
▸ ALOX15 P16050 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ MGAM O43451 1/20 0.42
▸ TPMT P51580 1/20 0.40
▸ CYP2C9 P11712 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ GABRP O00591 2/20 0.39
▸ GABRD O14764 2/20 0.39
▸ GABRA1 P14867 2/20 0.39
▸ GABRB1 P18505 2/20 0.39
▸ GABRG2 P18507 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31700802 1.00 HCAR2 (0.47) HCAR2POLBP4HA1P4HTMMIF
Nitrous Acid SCHEMBL27753209 0.93 HCAR2 (0.42) HCAR2POLBP4HA1P4HTMMIF
SCHEMBL7588782 0.84 RAB9A (0.36) P4HA1P4HTMMIFALDH1A1MEN1
SCHEMBL18348165 0.79 SMN1; SMN2 (0.38) KDM4EALDH1A1ALOX15HSD17B10CYP2C9
Formaldehyde SCHEMBL28058982 0.79 NNMT (0.41) LMNA
SCHEMBL487571 0.79 ATM (0.51) POLBKDM4EALDH1A1GABRA5LMNA
SCHEMBL846024 0.79 HCAR2 (0.50) HCAR2POLBP4HA1P4HTMMIF
SCHEMBL30792836 0.79 HCAR2 (0.50) HCAR2POLBP4HA1P4HTMMIF
SCHEMBL487368 0.79 HCAR2 (0.50) HCAR2POLBP4HA1P4HTMMIF
SCHEMBL15350036 0.78 HCAR2 (0.48) HCAR2POLBP4HA1P4HTMMIF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025034613-A1 3H-IMIDAZO[4,5-B]PYRIDINE COMPOUNDS AS NON-COVALENT MODIFIERS OF AKT1 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. (US) 2025-02-13 — — WO disclosed
WO-2024151919-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2024-07-18 — — WO disclosed
WO-2024151919-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2024-07-18 — — WO disclosed
EP-3953360-B1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MONOACYLGLYCEROL LIPASE (MAGL) HOFFMANN LA ROCHE (CH) 2024-02-28 — — EP disclosed
CN-112898289-B Compounds for modulating FXR activity and uses thereof 甘莱制药有限公司 2022-11-04 — — CN disclosed
CN-112891348-B Use of phenyl isoxazolyl methylene-naphthalene-ether derivatives and pharmaceutical compositions 甘莱制药有限公司 2022-06-28 — — CN disclosed
CN-112898289-A Compounds for modulating FXR activity and uses thereof 甘莱制药有限公司 2021-06-04 — — CN disclosed
CN-112891348-A Use and pharmaceutical composition of phenyl isoxazolyl methylene-naphthalene-ether derivatives 甘莱制药有限公司 2021-06-04 — — CN disclosed
US-9926308-B2 N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2018-03-27 — — US disclosed
EP-2880027-B1 N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF BOEHRINGER INGELHEIM INT (DE) 2016-09-28 — — EP disclosed
US-20160159784-A1 N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2016-06-09 — — US disclosed
EP-2880027-A1 N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF Boehringer Ingelheim International GmbH (DE) 2015-06-10 — — EP disclosed
US-20140045823-A1 N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF NEUROCRINE BIOSCIENCES, INC. (US) 2014-02-13 — — US disclosed
WO-2014019967-A1 N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-02-06 — — WO disclosed
US-20080119451-A1 Novel Benzamide Derivatives ASTRAZENECA AB (SE) 2008-05-22 — — US disclosed
US-20080119451-A1 Novel Benzamide Derivatives ASTRAZENECA AB (SE) 2008-05-22 — — US disclosed
US-20080119451-A1 Novel Benzamide Derivatives ASTRAZENECA AB (SE) 2008-05-22 — — US disclosed
WO-2006077387-A2 NOVEL BENZAMIDE DERIVATIVES ASTRAZENECA AB (SE) 2006-07-27 — — WO disclosed
WO-2006077387-A2 NOVEL BENZAMIDE DERIVATIVES ASTRAZENECA AB (SE) 2006-07-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140045823-A1 N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF GPR180, GPR119, CNR1 HCAR2 4/4885POLB 4585/4885P4HA1 606/4885
US-20080119451-A1 Novel Benzamide Derivatives HDAC1, HDAC11, HDAC2 HCAR2 966/4885POLB 254/4885P4HA1 538/4885
US-20160159784-A1 N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF GPR119, FFAR1, FFAR2 HCAR2 19/4885POLB 4632/4885P4HA1 570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.