Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 2/20 | 0.30 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSG | P08311 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280609 | 1.00 | CYP3A4 (0.31) | CYP3A4CYP2C19HTTLMNAMEN1 | |
| SCHEMBL261165 | 0.74 | LMNA (0.37) | HTTLMNAMEN1ALDH1A1TP53 | |
| SCHEMBL8274565 | 0.74 | ALDH1A1 (0.36) | CYP3A4CYP2C19HTTLMNAMEN1 | |
| SCHEMBL261164 | 0.74 | LMNA (0.37) | HTTLMNAMEN1ALDH1A1TP53 | |
| SCHEMBL2637205 | 0.74 | LMNA (0.37) | HTTLMNAMEN1ALDH1A1TP53 | |
| SCHEMBL8274597 | 0.72 | — | — | |
| SCHEMBL31164267 | 0.71 | MEN1 (0.37) | HTTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL268058 | 0.71 | MEN1 (0.37) | HTTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL268067 | 0.71 | MEN1 (0.37) | HTTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL268072 | 0.71 | MEN1 (0.37) | HTTLMNAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134023-B2 | Preparation of pregabalin and related compounds | PFIZER INC (US) | 2012-03-13 | — | — | US | disclosed |
| US-20120015412-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2012-01-19 | — | — | US | disclosed |
| US-20110065168-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2011-03-17 | — | — | US | disclosed |
| US-7838686-B2 | Preparation of pregabalin and related compounds | PFIZER INC. (US) | 2010-11-23 | — | — | US | disclosed |
| EP-1831154-B1 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER LAMBERT CO (US) | 2010-01-13 | — | — | EP | disclosed |
| EP-2071032-A2 | The use of enzymatic resolution for the preparation of intermediates of pregabalin | Teva Pharmaceutical Industries Ltd (IL) | 2009-06-17 | — | — | EP | disclosed |
| EP-2067768-A1 | A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid | Dipharma Francis S.r.l. (IT) | 2009-06-10 | — | — | EP | disclosed |
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2009-02-12 | — | — | US | disclosed |
| EP-1992609-A1 | A process for the preparation of a (S)(+)-3-(aminomethyl)-5-methylhexanoic acid | Dipharma Francis S.r.l. (IT) | 2008-11-19 | — | — | EP | disclosed |
| WO-2008062460-A2 | CRYSTALLINE FORMS OF PREGABALIN | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |
| WO-2006000904-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | GABRE, GABRG1, GABRA6 | CYP3A4 119/4885CYP2C19 161/4885HTT 3176/4885 |
| US-20110065168-A1 | Preparation of Pregabalin and Related Compounds | GABRE, GABRG1, GABRA6 | CYP3A4 119/4885CYP2C19 161/4885HTT 3176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.