Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18723690 | 0.79 | TDP1 (0.47) | PTGS2PTGS1ARPTGIRALDH1A1 | |
| SCHEMBL28061534 | 0.75 | PTGIR (0.41) | PTGS2PTGS1ARPTGIRALDH1A1 | |
| SCHEMBL18723868 | 0.75 | PTGS1 (0.39) | PTGS2PTGS1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL18723828 | 0.74 | PTGS1 (0.41) | PTGS2PTGS1ARPTGIRALDH1A1 | |
| SCHEMBL27916620 | 0.74 | PTGS1 (0.39) | TUBB1PTGS2PTGS1CYP1A1CYP1A2 | |
| SCHEMBL27916545 | 0.74 | TUBB1 (0.49) | TUBB1PTGS2PTGS1ALOX5CYP1A1 | |
| SCHEMBL28061531 | 0.73 | PTGS1 (0.38) | TUBB1PTGS2PTGS1CYP1A1CYP1A2 | |
| SCHEMBL28061523 | 0.71 | ALDH1A1 (0.46) | PTGS2PTGS1PTGIRALDH1A1KDM4E | |
| SCHEMBL482369 | 0.71 | CA1 (0.65) | CYP1A1CYP1A2CYP1B1PTGIRALDH1A1 | |
| SCHEMBL28061510 | 0.70 | F2RL1 (0.51) | PTGS2PTGS1ALOX5CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |