Water

Water

SCHEMBL28061572

CCc1ccc2c(c1)C(=O)c1ccccc1C2=O.O

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 4/20 0.48
NPC1 O15118 6/20 0.96
RAB9A P51151 6/20 0.96
SMN1; SMN2 Q16637 5/20 0.96
ALDH1A1 P00352 5/20 0.96
MAPK1 P28482 4/20 0.96
MAPT P10636 4/20 0.96
LMNA P02545 2/20 0.96
L3MBTL1 Q9Y468 2/20 0.96
ELANE P08246 1/20 0.53
CASP3 P42574 2/20 0.51
SENP8 Q96LD8 2/20 0.51
SENP7 Q9BQF6 2/20 0.51
SENP6 Q9GZR1 2/20 0.51
ATM Q13315 1/20 0.51
PLA2G1B P04054 1/20 0.48
NFKB1 P19838 1/20 0.48
NFKB2 Q00653 1/20 0.48
RELA Q04206 1/20 0.48
ATG4B Q9Y4P1 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29352712 0.98 NPC1 (1.00) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
SCHEMBL36840 0.98 NPC1 (1.00) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
Anthraquinone SCHEMBL6310187 0.98 NPC1 (1.00) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
SCHEMBL7318179 0.96 NPC1 (0.96) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
SCHEMBL27590795 0.96 NPC1 (0.96) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
9,10-Phenanthrenequinone SCHEMBL6059381 0.94 NPC1 (0.92) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
Formaldehyde SCHEMBL28131826 0.94 NPC1 (0.92) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
SCHEMBL8670753 0.92 MAPT (0.89) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
SCHEMBL11881427 0.92 SMN1; SMN2 (0.88) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1
SCHEMBL19396241 0.92 SMN1; SMN2 (0.88) NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104178019-B A kind of pottery photocureable coating 苏州圣谱拉新材料科技有限公司 2016-08-17 CN claimed
CN-104178019-B A kind of pottery photocureable coating 苏州圣谱拉新材料科技有限公司 2016-08-17 CN disclosed