SCHEMBL28062827

SCHEMBL28062827

CC(C)(C)O[SiH2]c1ccc(Cl)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
LMNA P02545 2/20 0.36
CYP2A6 P11509 1/20 0.36
HTR2A P28223 2/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
HRH1 P35367 1/20 0.34
HTR2B P41595 1/20 0.34
CHRNA4 P43681 1/20 0.34
SLC6A3 Q01959 1/20 0.34
PPARA Q07869 3/20 0.34
CYP1A2 P05177 2/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C19 P33261 1/20 0.34
TSHR P16473 3/20 0.33
MAPK1 P28482 2/20 0.33
HIF1A Q16665 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL704585 0.88
SCHEMBL22551525 0.77
SCHEMBL715568 0.76 MAPK1 (0.37) SLC6A2TSHRMAPK1TDP1
SCHEMBL14437832 0.74 ALDH1A1 (0.38) LMNASLC6A4CHRNA4CYP1A2CYP3A4
SCHEMBL3482167 0.74 LPL (0.39) LMNACYP2A6CYP2C19TSHRMAPK1
1,4-Dichlorobenzene SCHEMBL8932745 0.71 LMNA (0.61) MEN1KMT2ALMNACYP2A6HTR2A
SCHEMBL2950779 0.70
SCHEMBL31416082 0.68 LMNA (0.36) MEN1KMT2ALMNACYP2A6HTR2A
SCHEMBL6744235 0.67 KIF11 (0.34)
SCHEMBL28729098 0.67 LMNA (0.40) LMNACYP2A6SLC6A4TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105555901-A Polishing composition FUJIMI INC 2016-05-04 CN disclosed