SCHEMBL28064071

SCHEMBL28064071

O=C(Cc1cscn1)ON1CCC(CCOc2cccc(Cl)c2Cl)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
KMT2A Q03164 2/20 0.38
GAA P10253 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MGLL Q99685 1/20 0.38
KDM4E B2RXH2 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MEN1 O00255 1/20 0.37
HPGD P15428 2/20 0.35
SIGMAR1 Q99720 1/20 0.35
PPARG P37231 2/20 0.34
PPARD Q03181 2/20 0.34
PPARA Q07869 2/20 0.34
HTR7 P34969 2/20 0.34
DRD2 P14416 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
HTR1A P08908 1/20 0.34
HTR6 P50406 1/20 0.34
P2RX7 Q99572 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28064077 0.85 KDM4E (0.44) ALDH1A1KMT2AGAAL3MBTL1KDM4E
SCHEMBL28088351 0.84 PPARG (0.40) ALDH1A1KMT2AKDM4ESMN1; SMN2MEN1
SCHEMBL28064072 0.83 ALDH1A1 (0.39) ALDH1A1KMT2AMGLLKDM4ESMN1; SMN2
SCHEMBL28064062 0.83 RAB9A (0.39) ALDH1A1KMT2AMEN1HPGDPPARG
SCHEMBL28064163 0.83 ALDH1A1 (0.38) ALDH1A1KMT2AGAAL3MBTL1KDM4E
SCHEMBL28064089 0.83 PTGDR2 (0.40) MGLLPPARGHTR7DRD2HTR1A
SCHEMBL28827928 0.82 MEN1 (0.39) KMT2ASMN1; SMN2MEN1ACHEGSK3B
SCHEMBL2227294 0.81 MGLL (0.43) ALDH1A1KMT2AGAAL3MBTL1MGLL
SCHEMBL28064164 0.81 SIGMAR1 (0.38) ALDH1A1KMT2AGAAL3MBTL1KDM4E
SCHEMBL28088346 0.81 RAB9A (0.38) ALDH1A1KDM4ESMN1; SMN2HPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102803258-B Alkyl-heterocyclic carbamate derivatives, their preparation and therapeutic use SAI NUOFEI (FR) 2016-04-20 CN claimed
CN-105837565-A ALKYL-HETEROCYCLE CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 赛诺菲 2016-08-10 CN disclosed
CN-102803258-B Alkyl-heterocyclic carbamate derivatives, their preparation and therapeutic use SAI NUOFEI (FR) 2016-04-20 CN disclosed