Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL8616286 | 0.93 | MAPT (0.42) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL17938713 | 0.88 | MAPT (0.43) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL4748243 | 0.88 | MAPT (0.47) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL15845959 | 0.88 | MAPT (0.47) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL1146 | 0.88 | MAPT (0.47) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL434089 | 0.88 | MAPT (0.47) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| SCHEMBL6048117 | 0.86 | LMNA (0.62) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL342588 | 0.85 | MAPT (0.47) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| SCHEMBL23528233 | 0.84 | MAPT (0.46) | LMNAMAPTCYP1A2CYP2C9HPGD | |
| Trolamine SCHEMBL2051249 | 0.84 | MAPT (0.44) | MAPTCYP1A2CYP2C9HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110183435-A | A kind of oxazole class drug molecule and preparation method thereof for hospital's sterilization | 河南科技大学第一附属医院 | 2019-08-30 | — | — | CN | claimed |
| CN-110183435-A | A kind of oxazole class drug molecule and preparation method thereof for hospital's sterilization | 河南科技大学第一附属医院 | 2019-08-30 | — | — | CN | disclosed |
| CN-105732638-B | A kind of bruton's tyrosine kinase inhibitor with loop coil or caged scaffold and preparation method thereof | 成都倍特药业有限公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-106795099-A | Novel prodrugs and compositions for the treatment of hypertension and cardiovascular diseases | 南京奥昭生物科技有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106715533-A | Polyoxazoline antibody drug conjugates | 塞瑞纳治疗公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-106083962-A | A kind of compound with cyclophosphamide structure and preparation method thereof | 成都倍特药业有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-104169273-B | Dihydrofuran azetidine derivatives as antiparasitic | 硕腾服务有限责任公司 | 2016-11-02 | — | — | CN | disclosed |
| CN-103732588-B | Spiro molecules is as kinases inhibitor | 南京奥昭生物科技有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-103096875-B | Biodegradable lipid for delivery of active agent | 阿尔尼拉姆医药品有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105801603-A | ALK inhibitor with macrocyclic structure and preparation method thereof | 成都倍特药业有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105732638-A | Bruton tyrosine kinase inhibitor with spiro or bridge ring structure and preparation method thereof | 成都倍特药业有限公司 | 2016-07-06 | — | — | CN | disclosed |