Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 3/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1676924 | 0.87 | ENPP2 (0.59) | SMN1; SMN2ENPP2ALDH1A1 | |
| SCHEMBL28085472 | 0.85 | LTA4H (0.58) | ENPP2LTA4HMEN1ALDH1A1MAPT | |
| SCHEMBL10709191 | 0.84 | SMN1; SMN2 (0.80) | SMN1; SMN2MTNR1BMTNR1APGRLTA4H | |
| SCHEMBL11049862 | 0.82 | SMN1; SMN2 (0.77) | SMN1; SMN2MTNR1BMTNR1APGRLTA4H | |
| SCHEMBL257918 | 0.82 | ENPP2 (0.65) | SMN1; SMN2MTNR1BMTNR1AENPP2PGR | |
| SCHEMBL1943711 | 0.81 | LTA4H (0.50) | SMN1; SMN2LTA4HKDM4EMEN1MITF | |
| SCHEMBL4608736 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2MTNR1BMTNR1APGRLTA4H | |
| SCHEMBL29929943 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2MTNR1BMTNR1AENPP2PGR | |
| SCHEMBL30053231 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2MTNR1BMTNR1AENPP2PGR | |
| SCHEMBL1061713 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2MTNR1BMTNR1AENPP2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104844609-B | The irreversible bruton's tyrosine kinase inhibitor of dibit point | 杭州和正医药有限公司 | 2016-07-13 | — | — | CN | disclosed |