Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morclofone SCHEMBL554800 | 0.82 | SYK (0.60) | KMT2ALMNASYKSMN1; SMN2KCNA5 | |
| Tipepidine SCHEMBL410090 | 0.68 | NOS3 (0.43) | KMT2ALMNASMN1; SMN2MEN1TSHR | |
| SCHEMBL4711038 | 0.68 | SYK (0.70) | KMT2ASYKSMN1; SMN2MEN1TSHR | |
| Tipepidine SCHEMBL30827547 | 0.67 | NOS3 (0.42) | KMT2ALMNASMN1; SMN2MEN1TSHR | |
| SCHEMBL2088816 | 0.67 | SYK (0.68) | KMT2ALMNASYKSMN1; SMN2MEN1 | |
| Tipepidine SCHEMBL11026418 | 0.67 | HPGDS (0.43) | KMT2ALMNASMN1; SMN2MEN1TSHR | |
| SCHEMBL23195558 | 0.64 | KDM4E (0.61) | KMT2ALMNASYKSMN1; SMN2MEN1 | |
| SCHEMBL3930808 | 0.64 | KDM4E (0.61) | LMNASYKSMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL17610025 | 0.63 | ALDH1A1 (0.55) | KMT2ATSHRALDH1A1MAPTKDM4E | |
| SCHEMBL24177757 | 0.62 | LMNA (0.97) | KMT2ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |