Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Cinolazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cinolazepam SCHEMBL4457397 | 0.84 | OPRK1 (0.53) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| Cinolazepam SCHEMBL415075 | 0.84 | OPRK1 (0.53) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| Cinolazepam SCHEMBL30338063 | 0.84 | OPRK1 (0.53) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| Cinolazepam SCHEMBL28142897 | 0.81 | OPRK1 (0.50) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| SCHEMBL7330064 | 0.76 | OPRK1 (0.67) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| SCHEMBL7320833 | 0.75 | OPRK1 (0.66) | OPRK1KCNH2CHRM2ADRA2APDE4D | |
| Doxefazepam SCHEMBL31128398 | 0.74 | OPRK1 (0.57) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| Doxefazepam SCHEMBL554909 | 0.74 | OPRK1 (0.57) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| SCHEMBL7332842 | 0.73 | CCKBR (0.47) | OPRK1HTR1ADRD3HTR3AKCNH2 | |
| SCHEMBL7323323 | 0.71 | CCKBR (0.49) | OPRK1HTR1ADRD3HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |