Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adinazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 known ✓ | P47869 | 7/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alprazolam SCHEMBL3664716 | 0.89 | GABRA1 (0.66) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| SCHEMBL7425412 | 0.83 | GABRA1 (0.73) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| SCHEMBL7434779 | 0.83 | OPRK1 (0.74) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| Diazepam SCHEMBL8329713 | 0.83 | ADRA1A (0.64) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| Adinazolam SCHEMBL29358737 | 0.79 | OPRK1 (1.00) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| SCHEMBL11350197 | 0.79 | OPRK1 (0.77) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| Adinazolam SCHEMBL35430 | 0.79 | OPRK1 (1.00) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| SCHEMBL11829771 | 0.79 | GABRA3 (0.65) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| SCHEMBL11711028 | 0.76 | OPRK1 (0.63) | OPRK1ADRA1AGABRA1GABRA5GABRA2 | |
| SCHEMBL11603673 | 0.76 | GABRA1 (0.70) | OPRK1ADRA1AGABRA1GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |