SCHEMBL28091172

SCHEMBL28091172

CCc1ccc(O)c(NC(C)C)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.53
IDO1 P14902 2/20 0.44
ALOX15 P16050 4/20 0.40
ALOX12 P18054 4/20 0.40
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
HSD17B10 Q99714 3/20 0.40
ADRA2B P18089 3/20 0.40
ADRA1A P35348 3/20 0.40
MEN1 O00255 2/20 0.40
ESR1 P03372 2/20 0.40
TP53 P04637 2/20 0.40
CYP3A4 P08684 2/20 0.40
HPGD P15428 2/20 0.40
MAPK1 P28482 2/20 0.40
RECQL P46063 2/20 0.40
KMT2A Q03164 2/20 0.40
HIF1A Q16665 2/20 0.40
USP2 O75604 2/20 0.40
MAPT P10636 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13754317 0.79 TRPA1 (0.59) TRPA1IDO1ALOX15ALOX12KDM4E
SCHEMBL4543829 0.76 IDO1 (0.50) IDO1KDM4EMAPTPOLBRAB9A
SCHEMBL10922240 0.76 KDM5A (0.45) TRPA1ADRA1ACYP3A4MAPK1POLB
SCHEMBL28533528 0.75 ADRB2 (0.43) IDO1ALOX15KDM4EALDH1A1HSD17B10
SCHEMBL28091168 0.75 GAA (0.49) TRPA1IDO1ALOX15ALOX12ALDH1A1
SCHEMBL28091175 0.74 TRPA1 (0.53) TRPA1IDO1ALOX15ALOX12KDM4E
SCHEMBL10926167 0.74 CA12 (0.47) TRPA1ALDH1A1ADRA2BADRA1AMEN1
SCHEMBL19381672 0.73 ALOX5 (0.50) IDO1ALOX15ALOX12KDM4EALDH1A1
SCHEMBL12890447 0.73 IDO1 (0.47) IDO1ALDH1A1MEN1KMT2AMAPT
SCHEMBL13754306 0.73 POLB (0.54) TRPA1KDM4EALDH1A1HSD17B10MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105802610-B Fluorine ion fluorescent probe and application 中国科学院理化技术研究所 2018-05-04 CN disclosed
CN-105802610-A Fluorine ion fluorescent probe and application 中国科学院理化技术研究所 2016-07-27 CN disclosed