Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31545183 | 1.00 | PNMT (0.48) | PNMTDRD3DRD2IKBKBKDM1A | |
| SCHEMBL28195536 | 0.84 | DRD2 (0.51) | PNMTDRD3DRD2IKBKBKDM1A | |
| SCHEMBL29618357 | 0.76 | PNMT (0.60) | PNMTDRD3DRD2KDM1AALDH1A1 | |
| SCHEMBL8222195 | 0.76 | PNMT (0.60) | PNMTDRD3DRD2KDM1AALDH1A1 | |
| SCHEMBL29274045 | 0.75 | PNMT (0.42) | PNMTDRD3DRD2KDM1ACYP2A6 | |
| SCHEMBL6739755 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL30894888 | 0.74 | PNMT (0.58) | PNMTDRD3DRD2KDM1AALDH1A1 | |
| Bromide SCHEMBL17202846 | 0.73 | PNMT (0.52) | PNMTDRD3DRD2KDM1ACYP2A6 | |
| SCHEMBL30950987 | 0.73 | PNMT (0.52) | PNMTDRD3DRD2KDM1ATRPA1 | |
| SCHEMBL6014131 | 0.73 | PNMT (0.52) | PNMTDRD3DRD2KDM1ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119662-A1 | One Spot Synthesis of Citalopram from 5-Cyanophthalide | JUBILANT ORGANOSYS LIMTED (IN) | 2008-05-22 | — | — | US | claimed |
| EP-1723133-A1 | ONE POT SYNTHESIS OF CITALOPRAM FROM 5-CYANOPHTHALIDE | Jubilant Organosys Limited (IN) | 2006-11-22 | — | — | EP | claimed |
| EP-1601662-A1 | PROCESS FOR THE PREPARATION OF A CYANO-ISOBENZOFURAN | Adorkem Technology SpA (IT) | 2005-12-07 | — | — | EP | claimed |
| WO-2005077927-A1 | ONE POT SYNTHESIS OF CITALOPRAM FROM 5-CYANOPHTHALIDE | JUBILANT ORGANOSYS LIMITED (IN) | 2005-08-25 | — | — | WO | claimed |
| WO-2005070914-A1 | A METHOD FOR THE PREPARATION OF CITALOPRAM ACID ADDITION SALTS | JUBILANT ORGANOSYS LIMITED (IN) | 2005-08-04 | — | — | WO | claimed |
| EP-1095926-B1 | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate | SUMIKA FINE CHEMICALS CO LTD (JP) | 2004-10-06 | — | — | EP | claimed |
| WO-2004080988-A1 | PROCESS FOR THE PREPARATION OF A CYANO-ISOBENZOFURAN | ADORKEM TECHNOLOGY SPA (IT) | 2004-09-23 | — | — | WO | claimed |
| US-20040044232-A1 | Production methods of citalopram and intermediates therefor | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-03-04 | — | — | US | claimed |
| EP-1346989-A1 | Improved process for the preparation of citalopram and its hydrobromide | Jubilant Organosys Limited (IN) | 2003-09-24 | — | — | EP | claimed |
| US-20020151728-A1 | Production methods of 5-phthalancarbonitrile compound and an intermediate therefor | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-10-17 | — | — | US | claimed |
| US-6433195-B1 | 4-HALO-M-XYLYLENE GLYCOLS, ESTERS, ETHERS, AND TRIALKYLSILYL DERIVATEVES AS NOVEL INTERMEDIATES FOR CITALOPRAM PRODUCTION | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-08-13 | — | — | US | claimed |
| US-20020045770-A1 | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-04-18 | — | — | US | claimed |
| US-20010056194-A1 | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-12-27 | — | — | US | claimed |
| EP-1095926-A2 | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2001-05-02 | — | — | EP | claimed |
| WO-2019032147-A1 | TRANSDERMAL DRUG DELIVERY SYSTEM | AVRO LIFE SCIENCES, INC. (CA) | 2019-02-14 | — | — | WO | disclosed |
| CN-106632182-A | Preparation method of escitalopram oxalate demethylation impurity | 万全万特制药（厦门）有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-104829571-A | Escitalopram oxalate related substance and preparation method thereof | LIANYUNGANG HENGYUN MEDICAL TECHNOLOGY CO LTD | 2015-08-12 | — | — | CN | disclosed |
| CN-1286688-A | Process for the preparation of citalopram | LUNDHECK AS H (DK) | 2001-03-07 | — | — | CN | disclosed |
| WO-1996031172-A1 | VETERINARY METHOD FOR CLINICALLY MODIFYING THE BEHAVIOR OF DOGS EXHIBITING CANINE AFFECTIVE AGGRESSION | TRUSTEES OF TUFTS COLLEGE (US) | 1996-10-10 | — | — | WO | disclosed |
| US-5554383-A | ADMINISTERING SELECTIVE SEROTONIN REUPTAKE INHIBITOR | TRUSTEES OF TUFTS COLLEGE (US) | 1996-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119662-A1 | One Spot Synthesis of Citalopram from 5-Cyanophthalide | GRHPR, HTR3C, FKBP5 | PNMT 29/4885DRD3 936/4885DRD2 1284/4885 |
| US-20010056194-A1 | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate | SLC39A11, CYP4F11, SLC39A14 | PNMT 2986/4885DRD3 4575/4885DRD2 3952/4885 |
| US-20020045770-A1 | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate | SLC39A11, CYP4F11, SLC39A14 | PNMT 2986/4885DRD3 4575/4885DRD2 3952/4885 |
| US-20020151728-A1 | Production methods of 5-phthalancarbonitrile compound and an intermediate therefor | SLC39A11, CYP4F11, SLC39A14 | PNMT 3134/4885DRD3 4684/4885DRD2 4200/4885 |
| US-20040044232-A1 | Production methods of citalopram and intermediates therefor | PPIF, SLC39A11, CYP4F11 | PNMT 554/4885DRD3 1751/4885DRD2 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.