Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 2/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809384 | 0.85 | SIGMAR1 (0.54) | SIGMAR1 | |
| SCHEMBL2787920 | 0.81 | HRH1 (0.63) | HRH1HRH4HTR2CMEN1KMT2A | |
| SCHEMBL2807894 | 0.79 | ALDH1A1 (0.53) | HRH1HRH4HTR2CSIGMAR1MEN1 | |
| SCHEMBL2786539 | 0.78 | PDE1A (0.42) | PDE1APDE1BPDE1CKMT2ACYP3A4 | |
| SCHEMBL2856618 | 0.75 | CTNNB1 (0.46) | HTR2CSIGMAR1MEN1KMT2A | |
| SCHEMBL2786942 | 0.74 | HRH4 (0.54) | HRH4HTR2CLMNASRCMAPK1 | |
| SCHEMBL21282879 | 0.73 | SRC (0.45) | PDE1APDE1BPDE1CSRC | |
| SCHEMBL2807570 | 0.71 | PIK3CA (0.56) | HTR2CSRCPIK3CA | |
| SCHEMBL2882852 | 0.71 | HTR2C (0.61) | HTR2CSRCPIK3CA | |
| SCHEMBL2835938 | 0.71 | SLC2A1 (0.48) | HRH1HRH4MEN1KMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118367-A2 | ANTIVIRAL PYRIMIDINES | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |