Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.62 |
| ▸ | MMP2 | P08253 | 6/20 | 0.62 |
| ▸ | MMP9 | P14780 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PTPRF | P10586 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5283944 | 0.85 | ALDH1A1 (0.71) | RAB9APTPN1MMP2MMP9ALDH1A1 | |
| SCHEMBL10194271 | 0.82 | RAB9A (0.64) | RAB9APTPN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL24279764 | 0.80 | MMP2 (0.57) | RAB9AMMP2MMP9ALDH1A1KMT2A | |
| SCHEMBL10194276 | 0.79 | ALDH1A1 (0.59) | RAB9AMMP2MMP9ALDH1A1KMT2A | |
| SCHEMBL14427561 | 0.79 | MCOLN3 (0.67) | ALDH1A1KMT2AKDM4EGLAMEN1 | |
| SCHEMBL5568657 | 0.78 | NR1I2 (0.65) | PTPN1ALDH1A1KMT2AKDM4EGLA | |
| SCHEMBL4935879 | 0.77 | KEAP1 (0.65) | RAB9AMMP2MMP9ALDH1A1KMT2A | |
| SCHEMBL8911970 | 0.76 | ALDH1A1 (0.46) | RAB9APTPN1MMP2MMP9ALDH1A1 | |
| SCHEMBL1120401 | 0.75 | ALDH1A1 (0.45) | RAB9APTPN1MMP2MMP9ALDH1A1 | |
| SCHEMBL6318614 | 0.74 | ALDH1A1 (0.48) | RAB9APTPN1MMP2MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106344552-A | Novel sulfonamide compound, preparation method, and use of novel sulfonamide compound as protein tyrosine phosphatase 1B inhibitor | 齐鲁工业大学 | 2017-01-25 | — | — | CN | disclosed |
| CN-106349122-A | Novel substituted sulfamide compound, preparation method and application thereof as PTP1B inhibitor | 齐鲁工业大学 | 2017-01-25 | — | — | CN | disclosed |