Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 7/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28115079 | 0.86 | KMT2A (0.68) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28115078 | 0.86 | LMNA (0.65) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL29603721 | 0.81 | KMT2A (1.00) | KMT2AATMLMNACYP1A2CYP2C9 | |
| SCHEMBL28115080 | 0.77 | ALDH1A1 (0.59) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28246626 | 0.77 | KMT2A (0.58) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL13195186 | 0.76 | ALDH1A1 (0.67) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL17294235 | 0.76 | KMT2A (0.64) | KMT2AATMLMNAL3MBTL1CYP1A2 | |
| SCHEMBL25009812 | 0.75 | L3MBTL1 (0.76) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL30556174 | 0.75 | L3MBTL1 (0.76) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL8537983 | 0.75 | ALDH1A1 (0.69) | KMT2AATMLMNAL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146490-A | 5-hydroxyl-1,7-naphthyridine compounds, its preparation method and the pharmaceutical applications thereof replaced by aryloxy group or heteroaryloxy | 沈阳三生制药有限责任公司 | 2016-11-23 | — | — | CN | disclosed |