Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28115077 | 0.86 | KMT2A (0.68) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28115078 | 0.86 | LMNA (0.65) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL14937230 | 0.83 | KMT2A (0.72) | KMT2ALMNAL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL13195186 | 0.82 | ALDH1A1 (0.67) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL31006272 | 0.81 | KMT2A (1.00) | KMT2ALMNACYP1A2CYP2C9TSHR | |
| SCHEMBL23432070 | 0.80 | ALDH1A1 (0.63) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28085654 | 0.78 | HDAC3 (0.61) | KMT2ALMNAL3MBTL1ALDH1A1USP2 | |
| SCHEMBL13195870 | 0.78 | L3MBTL1 (0.61) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28115080 | 0.77 | ALDH1A1 (0.59) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28246626 | 0.77 | KMT2A (0.58) | KMT2ALMNAL3MBTL1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146490-A | 5-hydroxyl-1,7-naphthyridine compounds, its preparation method and the pharmaceutical applications thereof replaced by aryloxy group or heteroaryloxy | 沈阳三生制药有限责任公司 | 2016-11-23 | — | — | CN | disclosed |