Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.96 |
| ▸ | CXCR4 | P61073 | 10/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | CCR2 | P41597 | 1/20 | 0.67 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | MC4R | P32245 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10063607 | 1.00 | SIGMAR1 (0.96) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| SCHEMBL7062479 | 1.00 | SIGMAR1 (0.96) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| Hydrochloric Acid SCHEMBL8034018 | 0.98 | SIGMAR1 (0.92) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| SCHEMBL9538814 | 0.98 | SIGMAR1 (0.92) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| Bromide SCHEMBL21961924 | 0.98 | SIGMAR1 (0.92) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| SCHEMBL6138636 | 0.98 | SIGMAR1 (1.00) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| SCHEMBL83548 | 0.98 | SIGMAR1 (1.00) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| SCHEMBL152631 | 0.98 | SIGMAR1 (1.00) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| SCHEMBL276363 | 0.98 | SIGMAR1 (1.00) | SIGMAR1CXCR4MEN1KMT2ACHRM2 | |
| Benzene SCHEMBL27761330 | 0.98 | SIGMAR1 (1.00) | SIGMAR1CXCR4MEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110248969-A | Method for continuous synthesis of modified diene elastomers using lithium amide initiators | 米其林集团总公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-110114228-A | Tire tread comprising modified elastomer | 米其林集团总公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-109311980-A | G protein-coupled receptor (GPCR) modulation by emilienone (IMIPRIDONES) | 昂克希尔迪克斯有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-107121899-A | Anticorrosive additive stripping liquid controlling composition | 东友精细化工有限公司 | 2017-09-01 | — | — | CN | disclosed |
| CN-107110859-A | Analyzing device | 智能指纹有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-106188079-A | 7 piperazine thioureas of camptothecine, preparation method and purposes | 兰州大学 | 2016-12-07 | — | — | CN | disclosed |