Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29953891 | 0.78 | MAPT (0.59) | KDM4EALDH1A1MAPTGAACASP1 | |
| SCHEMBL28012374 | 0.78 | ALDH1A1 (0.49) | KDM4EEGFRSRCALDH1A1MAPT | |
| SCHEMBL1781653 | 0.78 | MAPT (0.59) | KDM4EALDH1A1MAPTGAACASP1 | |
| SCHEMBL3868019 | 0.75 | MAPT (0.65) | KDM4EEGFRALDH1A1MAPTGAA | |
| SCHEMBL29128851 | 0.75 | HTR6 (0.52) | KDM4EEGFRSRCALDH1A1MAPT | |
| SCHEMBL1557504 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1MAPTGAAATM | |
| SCHEMBL5460837 | 0.75 | ALDH1A1 (0.44) | KDM4EEGFRALDH1A1MAPTGAA | |
| SCHEMBL5144476 | 0.74 | EGFR (0.58) | KDM4EEGFRSRCALDH1A1MAPT | |
| SCHEMBL28283806 | 0.73 | CNR1 (0.55) | — | |
| SCHEMBL12355450 | 0.73 | CHRNB2 (0.60) | KDM4EALDH1A1MAPTGAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109106713-A | Indole-3-carbinol, di-indole methyl hydride and its derivative are preparing the application in treating organs graft-rejection drug | 黄冈昌耀电力器材有限公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-106344563-A | Application of indole-3-carbinol and diindolylmethane and derivatives thereof in preparation of medicines for treating lupus erythematosus | 安徽四正医药科技有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-106344564-A | Application of indole-3-carbinol and diindolylmethane and derivatives thereof in preparation of medicines for treating hair follicle keratosis | 安徽四正医药科技有限公司 | 2017-01-25 | — | — | CN | disclosed |