Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360155 | 0.80 | MAPT (0.56) | MAPTCYP3A4HTR6HTR2AHTR2C | |
| SCHEMBL28012374 | 0.79 | ALDH1A1 (0.49) | MAPTCYP3A4HTR6KDM4EALDH1A1 | |
| 2-Methyl Gramine SCHEMBL2519973 | 0.79 | MAPT (1.00) | MAPTCYP3A4HTR6HTR2AHTR2C | |
| SCHEMBL11493599 | 0.77 | MAPT (0.56) | MAPTCYP3A4HTR6HTR2AHTR2C | |
| SCHEMBL11495544 | 0.77 | MAPT (0.56) | MAPTCYP3A4HTR6HTR2AHTR2C | |
| SCHEMBL29128851 | 0.77 | HTR6 (0.52) | MAPTCYP3A4HTR6HTR2AHTR2C | |
| SCHEMBL28115779 | 0.75 | KDM4E (0.42) | MAPTCYP3A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL5144476 | 0.75 | EGFR (0.58) | MAPTCYP3A4HTR6KDM4EALDH1A1 | |
| SCHEMBL11495830 | 0.75 | HTR2A (0.71) | MAPTCYP3A4HTR6HTR2AHTR2C | |
| SCHEMBL3233129 | 0.75 | CYP3A4 (0.67) | MAPTCYP3A4HTR6HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401410-A4 | IMMUNOMODULATION AND EFFECT ON CELL PROCESSES RELATING TO SEROTONIN FAMILY RECEPTORS | PHILADELPHIA HEALTH & EDUCATIO (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1534256-A4 | IMMUNOMODULATION AND EFFECT ON CELL PROCESSES RELATING TO SEROTONIN FAMILY RECEPTORS AND THE BLOOD-BRAIN BARRIER | PHILADELPHIA HEALTH & EDUCATIO (US) | 2007-06-20 | — | — | EP | disclosed |
| US-20060183757-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors and the blood-brain barrier | Philadelphia Health and | 2006-08-17 | — | — | US | disclosed |
| US-20060135415-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors and the blood-brain barrier | JAMESON BRADFORD A | 2006-06-22 | — | — | US | disclosed |
| US-20060039903-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors | JAMESON BRADFORD A | 2006-02-23 | — | — | US | disclosed |
| US-6979447-B2 | Immunomodulation and effect on cell processes relating to serotonin family receptors | PHILADELPHIA HEALTH AND EDUCATION CORPORATION (US) | 2005-12-27 | — | — | US | disclosed |
| EP-1534256-A2 | IMMUNOMODULATION AND EFFECT ON CELL PROCESSES RELATING TO SEROTONIN FAMILY RECEPTORS AND THE BLOOD-BRAIN BARRIER | Philadelphia Health and Education Corporation (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1401410-A2 | IMMUNOMODULATION AND EFFECT ON CELL PROCESSES RELATING TO SEROTONIN FAMILY RECEPTORS | Philadelphia Health and Education Corporation (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003106660-A2 | IMMUNOMODULATION AND EFFECT ON CELL PROCESSES RELATING TO SEROTONIN FAMILY RECEPTORS AND THE BLOOD-BRAIN BARRIER | PHILADELPHIA HEALTH AND EDUCATION CORPORATION (US) | 2003-12-24 | — | — | WO | disclosed |
| US-20030100570-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors | PHILADELPHIA HEALTH AND EDUCATION CORPORATION (D/B/A MCH HAHNEMANN UNIVERSITY) | 2003-05-29 | — | — | US | disclosed |
| WO-2002078643-A2 | IMMUNOMODULATION AND EFFECT ON CELL PROCESSES RELATING TO SEROTONIN FAMILY RECEPTORS | PHILADELPHIA HEALTH AND EDUCATION CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060039903-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors | HTR6, HTR3B, HTR4 | MAPT 3898/4885CYP3A4 2057/4885HTR6 1/4885 |
| US-20060135415-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors and the blood-brain barrier | HTR2A, HTR1B, HTR5A | MAPT 3115/4885CYP3A4 711/4885HTR6 4/4885 |
| US-20060183757-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors and the blood-brain barrier | HTR2A, HTR1B, HTR5A | MAPT 3115/4885CYP3A4 711/4885HTR6 4/4885 |
| US-20030100570-A1 | Immunomodulation and effect on cell processes relating to serotonin family receptors | HTR6, HTR3B, HTR4 | MAPT 3898/4885CYP3A4 2057/4885HTR6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.