Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070239 | 0.77 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL9620433 | 0.76 | GLO1 (0.36) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL9620431 | 0.76 | GLO1 (0.36) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL15046951 | 0.75 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL18431955 | 0.74 | FBP1 (0.36) | ALDH1A1LMNAHSD17B10GLO1CYP2C9 | |
| SCHEMBL28244012 | 0.73 | CYP2D6 (0.36) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL11461030 | 0.72 | ALDH1A1 (0.39) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL10467804 | 0.72 | ALDH1A1 (0.39) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL2915798 | 0.70 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 | |
| SCHEMBL10275655 | 0.69 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10GLO1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109354584-A | The method of one pot process 2- (4- hydroxy phenyl) -4- methyl-1,3-thiazole-5-carboxylic acid ethyl ester | 湖北理工学院 | 2019-02-19 | — | — | CN | claimed |
| CN-108570017-A | The synthesis of 2- amino-4-methylthiazole-5-carboxylates | 西安格瑞德化工新材料有限公司 | 2018-09-25 | — | — | CN | claimed |
| CN-108218702-A | The preparation method of 2- acetyl fluoride ethyl acetate | 湖北卓熙氟化股份有限公司 | 2018-06-29 | — | — | CN | claimed |
| CN-105753858-B | Heterocyclic compound and p27Kip1Decomposing inhibitor | ASKA制药株式会社 | 2019-04-30 | — | — | CN | disclosed |
| CN-109574952-A | A kind of synthetic method of febuxostat intermediate | 安徽省庆云医药股份有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-109574951-A | A kind of preparation method of Febuxostat | 安徽省庆云医药股份有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-109575018-A | A kind of anti-infective compounds | 韩国巴斯德研究所 | 2019-04-05 | — | — | CN | disclosed |
| CN-105622637-B | Thiazole simultaneously [3,2-b] -1,2,4- triazine -2- carboxylic acid derivates and its preparation method and application | 沈阳药科大学 | 2018-09-25 | — | — | CN | disclosed |
| CN-108218702-A | The preparation method of 2- acetyl fluoride ethyl acetate | 湖北卓熙氟化股份有限公司 | 2018-06-29 | — | — | CN | disclosed |
| CN-105777664-B | Carboxylate of 2 (2 benzyl hydrazono-) thiazole 5 and preparation method thereof and medical usage | 湖南大学 | 2017-12-29 | — | — | CN | disclosed |
| CN-206570248-U | A kind of continuous synthesis system of 4 chloroacetyl acetacetic ester | 江苏诚信药业有限公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-104781258-B | Hydroxy-substituted imidazo [1,2-a ] pyridinecarboxamides and their use as soluble guanylate cyclase stimulators | 拜耳制药股份公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-105745212-B | Spiro derivatives of substituted 4, 5-dihydropyrazolo [3,4-c ] pyridin-2-ones and uses thereof | 四川海思科制药有限公司 | 2017-09-12 | — | — | CN | disclosed |
| CN-106748764-A | The continuous synthesis system and method for a kind of 4 chloroacetyl acetacetic ester | 江苏诚信药业有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106752470-A | A kind of skin coating | 安徽钰锦生态木材料有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-105026392-B | 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof | 四川海思科制药有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-104529935-B | Method for synthesizing ethyl 2-(3-aldehyde-4-isobutyloxyphenyl)-4-methylthiazole-5-formate | 浙江华义医药有限公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-106543139-A | A kind of triadimefon compound and application thereof | 沈阳中化农药化工研发有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-106459037-A | Enantiomers of the n-(2-amino-5-fluoro-2-methylpentyl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide, as well as of the di- and trifluoro derivatives for the treatment of cardiovascular diseases | 拜耳医药股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106414440-A | Aryl and heteroaryl substituted imidazo [1,2-a ] pyridine-3-carboxamides and their use | 拜耳制药股份公司 | 2017-02-15 | — | — | CN | disclosed |