Sugi Predict

Sugi Predict / Compounds / SCHEMBL2811951

SCHEMBL2811951

SCHEMBL2811951

COC(=O)c1cc(C)c(N)cc1C(=O)OC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 8/20 0.53
▸ ALDH1A1 P00352 6/20 0.52
▸ HSD17B10 Q99714 3/20 0.52
▸ CFTR P13569 3/20 0.52
▸ GAA P10253 5/20 0.52
▸ HPGD P15428 3/20 0.52
▸ MAPT P10636 3/20 0.52
▸ GLA P06280 2/20 0.52
▸ CASP1 P29466 1/20 0.52
▸ CASP7 P55210 1/20 0.52
▸ ATM Q13315 1/20 0.52
▸ ABL1 P00519 1/20 0.50
▸ TSHR P16473 3/20 0.49
▸ ALOX15 P16050 1/20 0.49
▸ POLB P06746 1/20 0.44
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ CA12 O43570 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL274700 0.90 KDM4E (0.55) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL30280995 0.90 KDM4E (0.55) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL2318882 0.90 KDM4E (0.55) KDM4EALDH1A1HSD17B10CFTRGAA
Hydrochloric Acid SCHEMBL5417457 0.88 KDM4E (0.53) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL22535980 0.87 KDM4E (0.61) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL1770853 0.86 KDM4E (0.49) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL2897750 0.86 KDM4E (0.61) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL23774898 0.85 GAA (0.54) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL11385067 0.85 GAA (0.63) KDM4EALDH1A1HSD17B10CFTRGAA
SCHEMBL31508216 0.85 GAA (0.54) KDM4EALDH1A1HSD17B10CFTRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656642-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF GAN & LEE PHARM CO., LTD (CN) 2025-12-03 — — EP disclosed
US-20250129088-A1 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR GAN & LEE PHARMACEUTICALS CO., LTD. (CN) 2025-04-24 — — US disclosed
WO-2025026283-A1 COMPOUND FOR SELECTIVELY DEGRADING SMARCA2/4 AND USE THEREOF 甘李药业股份有限公司 2025-02-06 — — WO disclosed
EP-4471033-A1 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR Gan & Lee Pharmaceuticals Co., Ltd. (CN) 2024-12-04 — — EP disclosed
CN-118632848-A Cerebellar protein E3 ubiquitin ligase inhibitors 甘李药业股份有限公司 2024-09-10 — — CN disclosed
WO-2024156294-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF 甘李药业股份有限公司 2024-08-02 — — WO disclosed
EP-3426246-B1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF NATIONAL HEALTH RES INST (TW) 2024-05-01 — — EP disclosed
WO-2023143589-A1 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR 甘李药业股份有限公司 2023-08-03 — — WO disclosed
US-20230036854-A1 HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS THE UNIVERSITY OF SHEFFIELD (GB) 2023-02-02 — — US disclosed
US-20230036854-A1 HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS THE UNIVERSITY OF SHEFFIELD (GB) 2023-02-02 — — US disclosed
US-20170253569-A1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF REGENTS OF THE UNIVERSITY OF MINNESOTA 2017-09-07 — — US disclosed
US-7807670-B2 Inhibitors of papilloma virus BOEHRINGER INGELHEIM CANADA LTD. (CA) 2010-10-05 — — US disclosed
US-7807670-B2 Inhibitors of papilloma virus BOEHRINGER INGELHEIM CANADA LTD. (CA) 2010-10-05 — — US disclosed
US-20100240908-A1 ACETYLENE COMPOUND FUJIFILM CORPORATION (JP) 2010-09-23 — — US disclosed
EP-2202221-A1 ACETYLENE COMPOUND Fujifilm Corporation (JP) 2010-06-30 — — EP disclosed
US-20100041649-A1 INHIBITORS OF PAPILLOMA VIRUS YOAKIM CHRISTIANE 2010-02-18 — — US disclosed
US-20100041649-A1 INHIBITORS OF PAPILLOMA VIRUS YOAKIM CHRISTIANE 2010-02-18 — — US disclosed
US-7528167-B2 Inhibitors of papilloma virus BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2009-05-05 — — US disclosed
US-7528167-B2 Inhibitors of papilloma virus BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2009-05-05 — — US disclosed
EP-1345943-B1 INHIBITORS OF PAPILLOMA VIRUS BOEHRINGER INGELHEIM CA LTD (CA) 2007-03-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250129088-A1 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR CRBN, UBE3A, UBE3C KDM4E 1439/4885ALDH1A1 3364/4885HSD17B10 3427/4885
US-20100240908-A1 ACETYLENE COMPOUND NAT1, KATNA1, KAT2B KDM4E 3178/4885ALDH1A1 401/4885HSD17B10 534/4885
US-20100041649-A1 INHIBITORS OF PAPILLOMA VIRUS REV1, CDKN1A, RB1 KDM4E 919/4885ALDH1A1 532/4885HSD17B10 1985/4885
US-20230036854-A1 HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS MC2R, AGTR2, NR3C2 KDM4E 4724/4885ALDH1A1 2923/4885HSD17B10 2827/4885
US-20170253569-A1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF OPRL1, OPRD1, OPRK1 KDM4E 3848/4885ALDH1A1 295/4885HSD17B10 285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.