Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 8/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | PPIB | P23284 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7890024 | 1.00 | KLK5 (0.36) | KLK5RENALOX5APFEN1PROKR1 | |
| SCHEMBL2813838 | 1.00 | KLK5 (0.36) | KLK5RENALOX5APFEN1PROKR1 | |
| SCHEMBL7905913 | 0.94 | CACNA1B (0.35) | KLK5RENCYP3A4SCN9AACE | |
| SCHEMBL7891211 | 0.90 | PROKR1 (0.42) | KLK5RENPROKR1PPIBCYP3A4 | |
| SCHEMBL7902535 | 0.89 | USP30 (0.32) | KLK5RENCYP3A4SCN9AALDH1A1 | |
| SCHEMBL7897503 | 0.89 | SCN9A (0.32) | KLK5RENALOX5APFEN1CYP3A4 | |
| SCHEMBL2791534 | 0.88 | MMP13 (0.34) | KLK5PROKR1CYP3A4ALDH1A1 | |
| SCHEMBL7901258 | 0.88 | PABPC1 (0.33) | KLK5HRH2HRH1ITGB3ITGA2B | |
| SCHEMBL7897783 | 0.88 | PABPC1 (0.33) | KLK5 | |
| SCHEMBL7900833 | 0.88 | PABPC1 (0.34) | KLK5ACEHRH2HRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |