Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 5/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2812209 | 0.85 | MEN1 (0.44) | DGAT1HPSEKDM4EPOLBMEN1 | |
| SCHEMBL2814782 | 0.85 | HPSE (0.44) | DGAT1HPSESOAT1POLBMEN1 | |
| SCHEMBL2818258 | 0.85 | KIF11 (0.43) | DGAT1HPSESOAT1KDM4EPOLB | |
| SCHEMBL2819129 | 0.83 | MEN1 (0.47) | KDM4EMEN1KMT2AKDR | |
| SCHEMBL2812631 | 0.83 | EPHX2 (0.44) | HPSEMEN1KMT2ARORC | |
| SCHEMBL3989807 | 0.78 | FFAR1 (0.58) | DGAT1SOAT1KDM4E | |
| SCHEMBL2814672 | 0.77 | HPSE (0.52) | HPSEKDR | |
| SCHEMBL3994385 | 0.77 | NR1H4 (0.46) | DGAT1SOAT1MEN1KMT2A | |
| SCHEMBL2816860 | 0.75 | ADORA2B (0.43) | MEN1KMT2A | |
| SCHEMBL3993080 | 0.75 | NR1H4 (0.46) | DGAT1HPSESOAT1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | SDHA, SDHB, TPD52L2 | DGAT1 4383/4885HPSE 4848/4885SOAT1 3653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.