Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994385 | 0.81 | NR1H4 (0.46) | MAPTDGAT1NR1H4SOAT1CHEK2 | |
| SCHEMBL3993080 | 0.79 | NR1H4 (0.46) | DGAT1NR1H4SOAT1CHEK2SMN1; SMN2 | |
| SCHEMBL2816747 | 0.78 | DGAT1 (0.44) | KDM4EDGAT1SOAT1 | |
| SCHEMBL2814782 | 0.77 | HPSE (0.44) | MAPTHTTDGAT1SOAT1NPC1 | |
| SCHEMBL2812209 | 0.75 | MEN1 (0.44) | KDM4EDGAT1CHEK2 | |
| SCHEMBL2818258 | 0.75 | KIF11 (0.43) | KDM4EALDH1A1MAPTDGAT1SOAT1 | |
| SCHEMBL25231857 | 0.74 | MEN1 (0.58) | MAPTCHEK2NPC1RAB9A | |
| SCHEMBL2819129 | 0.73 | MEN1 (0.47) | KDM4EALDH1A1LMNAMAPTHTT | |
| SCHEMBL2812631 | 0.73 | EPHX2 (0.44) | MAPTCHEK2PARP1 | |
| SCHEMBL3993126 | 0.72 | DGAT1 (0.51) | LMNAMAPTHTTDGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362057-B2 | Insulin resistance; atherosclerosis; cardiovascular disorders; metabolism disorders | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-01-29 | — | — | US | disclosed |
| EP-1910310-B1 | NOVELIMIDAZOLECARBOXAMIDE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| US-20080207720-A1 | Novel Imidazolecarboxamide Derivatives as Fructose-1,6-Bisphosphatase Inhibitors, and Pharmaceutical Compositions Comprising Same | MERCK PATENT GESELLSCHAFT (DE) | 2008-08-28 | — | — | US | disclosed |
| EP-1910310-A1 | NOVELIMIDAZOLECARBOXAMIDE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007014619-A1 | NOVELIMIDAZOLECARBOXAMIDE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207720-A1 | Novel Imidazolecarboxamide Derivatives as Fructose-1,6-Bisphosphatase Inhibitors, and Pharmaceutical Compositions Comprising Same | FBP1, INSR, GPR119 | FFAR1 43/4885HPGD 1049/4885KDM4E 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.