Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2812209 | 0.89 | MEN1 (0.44) | POLBKDM4EMEN1KMT2ADGAT1 | |
| SCHEMBL2815672 | 0.85 | RAB9A (0.45) | KIF11MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2816747 | 0.85 | DGAT1 (0.44) | POLBKDM4EMEN1KMT2ADGAT1 | |
| SCHEMBL2812631 | 0.84 | EPHX2 (0.44) | KIF11MEN1KMT2AHPSERORC | |
| SCHEMBL2819129 | 0.82 | MEN1 (0.47) | KDM4EMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2817001 | 0.82 | KDM4E (0.46) | POLBKDM4EMEN1KMT2ARAB9A | |
| SCHEMBL2814782 | 0.78 | HPSE (0.44) | POLBMEN1KMT2ADGAT1HPSE | |
| SCHEMBL2816860 | 0.77 | ADORA2B (0.43) | MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3994385 | 0.76 | NR1H4 (0.46) | MEN1KMT2ADGAT1RAB9ASOAT1 | |
| SCHEMBL2816165 | 0.76 | COPS5 (0.43) | KIF11POLBMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | SDHA, SDHB, TPD52L2 | KIF11 2526/4885POLB 2686/4885KDM4E 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.