Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.34 |
| ▸ | HDAC4 known ✓ | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.32 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113386 | 0.96 | CYP3A4 (0.47) | CYP3A4GABRA1GABRB2SIGMAR1CASP3 | |
| Methane SCHEMBL27978530 | 0.95 | CYP3A4 (0.46) | CYP3A4GABRA1GABRB2SIGMAR1CASP3 | |
| Toluene SCHEMBL28897191 | 0.89 | CYP3A4 (0.49) | CYP3A4GABRA1GABRB2SIGMAR1CASP3 | |
| SCHEMBL6752522 | 0.82 | CYP3A4 (0.38) | CYP3A4GABRA1GABRB2CASP3SENP8 | |
| SCHEMBL9183951 | 0.82 | CYP3A4 (0.50) | CYP3A4GABRA1GABRB2ALDH1A1HPGD | |
| SCHEMBL185120 | 0.81 | CYP3A4 (0.48) | CYP3A4SIGMAR1CASP3SENP8SENP7 | |
| SCHEMBL29687996 | 0.81 | CYP3A4 (0.48) | CYP3A4SIGMAR1CASP3SENP8SENP7 | |
| Methane SCHEMBL27501832 | 0.80 | CYP3A4 (0.47) | CYP3A4SIGMAR1CASP3SENP8SENP7 | |
| SCHEMBL10734571 | 0.79 | CYP3A4 (0.38) | CYP3A4GABRA1GABRB2PARP10PARP11 | |
| SCHEMBL694840 | 0.77 | GABRA1 (0.39) | CYP3A4GABRA1GABRB2PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252118-C | Second-order non-linear optical polymer of isocyanate crosslinked epoxy resin | UNIV TSINGHUA (CN) | 2006-04-19 | — | — | CN | claimed |
| EP-2046882-B1 | FLAME RETARDANT THERMOPLASTIC COMPOSITION | DSM IP ASSETS BV (NL) | 2015-09-02 | — | — | EP | disclosed |
| US-20100249287-A1 | FLAME RETARDANT THERMOPLASTIC COMPOSITION AND MOULDED PART MADE THEREOF | DSM IP ASSETS B.V. (NL) | 2010-09-30 | — | — | US | disclosed |
| EP-2046882-A1 | FLAME RETARDANT THERMOPLASTIC COMPOSITION | DSMIP Assets B.V. (NL) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008011941-A1 | FLAME RETARDANT THERMOPLASTIC COMPOSITION | DSM IP ASSETS B.V. (NL) | 2008-01-31 | — | — | WO | disclosed |
| US-20060083953-A1 | Magnetic recording medium | FUJI PHOTO FILM CO., LTD. | 2006-04-20 | — | — | US | disclosed |
| CN-1226301-A | Method of applying powder coating to length of lignocellulosic material | WINDSOR TECHNOLOGY LTD (BS) | 1999-08-18 | — | — | CN | disclosed |
| EP-0277376-B1 | AROMATIC AMIDE GROUPS-CONTAINING DIAMINES AND POLYMERS IN WHICH THESE DIAMINES ARE INCORPORATED | AKZO N.V. (NL) | 1991-02-27 | — | — | EP | disclosed |
| US-4980444-A | Polyamides, polyureas, polyimides; heat resistance, melt processability, high strength fibers, films | AKZO N.V. (NL) | 1990-12-25 | — | — | US | disclosed |
| US-4851562-A | HEAT RESISTANCE, MELT PROCESS ABILITY | AKZO N.V. (NL) | 1989-07-25 | — | — | US | disclosed |
| US-4806414-A | THERMOPLASTIC POLYMERS WITH POLYESTER-ESTER URETHANE ADHESIVES | AKZO NV (NL) | 1989-02-21 | — | — | US | disclosed |
| EP-0277376-A1 | Aromatic amide groups-containing diamines and polymers in which these diamines are incorporated | AKZO N.V. (NL) | 1988-08-10 | — | — | EP | disclosed |
| EP-0102115-B1 | POLYESTER-ESTER URETHANE | AKZO N.V. (NL) | 1987-06-10 | — | — | EP | disclosed |
| EP-0213681-A1 | Composite material | AKZO N.V. (NL) | 1987-03-11 | — | — | EP | disclosed |
| EP-0159053-A1 | Polyester-ester urethane | AKZO N.V. (NL) | 1985-10-23 | — | — | EP | disclosed |
| US-4483970-A | BLOCK POLYMERS, MOLDING MATERIALS | AKZO N.V. (NL) | 1984-11-20 | — | — | US | disclosed |
| EP-0102115-A1 | Polyester-ester urethane | AKZO N.V. (NL) | 1984-03-07 | — | — | EP | disclosed |