Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | TEK | Q02763 | 6/20 | 0.46 |
| ▸ | BRAF | P15056 | 12/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2813498 | 0.89 | KDR (0.54) | KDRTEKBRAFRAF1 | |
| SCHEMBL2815366 | 0.88 | IDH1 (0.49) | KDR | |
| SCHEMBL2816387 | 0.87 | KDR (0.47) | KDRTEKBRAFRAF1 | |
| SCHEMBL2814866 | 0.87 | BRAF (0.48) | KDRTEKBRAF | |
| SCHEMBL2817151 | 0.86 | KCNMA1 (0.51) | KDRBRAF | |
| SCHEMBL2816885 | 0.84 | FBP1 (0.47) | KDRTEKBRAFRAF1 | |
| SCHEMBL2816767 | 0.82 | MEN1 (0.43) | — | |
| SCHEMBL2815550 | 0.81 | RAB9A (0.44) | KDR | |
| SCHEMBL17957280 | 0.81 | KDR (0.42) | KDRTEKBRAFRAF1 | |
| SCHEMBL2813209 | 0.80 | LMNA (0.47) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249132-A1 | IMIDAZOLE DERIVATIVES | SDHA, SDHB, TPD52L2 | KDR 1879/4885TEK 3843/4885BRAF 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.