Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755056 | 0.96 | GRM8 (0.52) | GRM8GRM4ALDH1A1MAPTCYP1A2 | |
| SCHEMBL9116030 | 0.85 | GRM8 (0.63) | GRM8GRM4CYP1A2 | |
| SCHEMBL21518512 | 0.85 | GRM8 (0.63) | GRM8GRM4CYP1A2 | |
| SCHEMBL16110126 | 0.84 | GRM8 (0.46) | GRM8GRM4ALDH1A1MAPTCYP1A2 | |
| SCHEMBL10616251 | 0.82 | CYP1A2 (0.54) | GRM8GRM4ALDH1A1MAPTCYP1A2 | |
| SCHEMBL3466061 | 0.80 | GRM8 (0.41) | GRM8GRM4ALDH1A1MAPTCYP1A2 | |
| SCHEMBL1031120 | 0.76 | TDP1 (0.53) | GRM8GRM4ALDH1A1MAPTCYP1A2 | |
| SCHEMBL7597653 | 0.76 | GSTP1 (0.47) | MEN1KMT2A | |
| SCHEMBL4073468 | 0.75 | CYP1A2 (0.68) | ALDH1A1MAPTCYP1A2GAATDP1 | |
| SCHEMBL1139053 | 0.75 | CYP1A2 (0.68) | ALDH1A1MAPTCYP1A2GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630555-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2026-05-19 | — | — | US | disclosed |
| US-20240409544-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | DREXEL UNIVERSITY | 2024-12-12 | — | — | US | disclosed |
| US-12152036-B2 | Substituted pyrrolo[1,2-α]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2024-11-26 | — | — | US | disclosed |
| US-20220144845-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | UNIV DREXEL (US) | 2022-05-12 | — | — | US | disclosed |
| US-11267817-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2022-03-08 | — | — | US | disclosed |
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | DREXEL UNIVERSITY | 2020-02-27 | — | — | US | disclosed |
| US-20190316169-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING A CELL IN A SAMPLE | SONANUTECH INC. (US) | 2019-10-17 | — | — | US | disclosed |
| US-20190271693-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING BACTERIOPHAGE IN A SAMPLE | SONANUTECH INC. (US) | 2019-09-05 | — | — | US | disclosed |
| WO-2018204370-A1 | CX3CR1 SMALL MOLECULE ANTAGONISTS, AND METHODS USING SAME | DREXEL UNIVERSITY (US) | 2018-11-08 | — | — | WO | disclosed |
| WO-2018098404-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING A CELL IN A SAMPLE | SONANUTECH INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098402-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING BACTERIOPHAGE IN A SAMPLE | SONANUTECH INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| WO-2010121066-A2 | SILICA NANOPARTICLES INCORPORATING CHEMILUMINESCENT AND ABSORBING ACTIVE MOLECULES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010071772-A2 | SYNTHESIS OF 3B-AMINO-5-CHOLESTENE AND RELATED 3B-HALIDES INVOLVING I-STEROID AND RETRO-I-STEROID REARRANGEMENTS | THE PENN STATE RESEARCH FOUNDATION (US) | 2010-06-24 | — | — | WO | disclosed |
| US-20100092470-A1 | ANTIBODIES, ANALOGS AND USES THEREOF | ICB INTERNATIONAL, INC. | 2010-04-15 | — | — | US | disclosed |
| WO-2010033913-A1 | ANTIBODIES, ANALOGS AND USES THEREOF | ICB INTERNATIONAL, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| US-7514400-B2 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20060229235-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240409544-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | CX3CR1, CCR5, CCL2 | GRM8 466/4885GRM4 218/4885ALDH1A1 2650/4885 |
| US-20220144845-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | CX3CR1, CCR5, CCL2 | GRM8 466/4885GRM4 218/4885ALDH1A1 2650/4885 |
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | CX3CR1, CCR5, CXCR3 | GRM8 1024/4885GRM4 545/4885ALDH1A1 3776/4885 |
| US-11267817-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCR5, CCL2 | GRM8 511/4885GRM4 194/4885ALDH1A1 2437/4885 |
| US-20060229235-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | MSR1, M6PR, ASGR1 | GRM8 316/4885GRM4 384/4885ALDH1A1 4719/4885 |
| US-12630555-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCL2, CCR2 | GRM8 654/4885GRM4 404/4885ALDH1A1 2597/4885 |
| US-12152036-B2 | Substituted pyrrolo[1,2-α]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCR5, CCL2 | GRM8 451/4885GRM4 212/4885ALDH1A1 2570/4885 |
| US-20100092470-A1 | ANTIBODIES, ANALOGS AND USES THEREOF | IGLV6-57, IGSF11, FCGR3B | GRM8 2723/4885GRM4 2121/4885ALDH1A1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.