SCHEMBL28192546

SCHEMBL28192546

NC(=O)Cc1ccc(CCNCCc2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 0.56
CA1 P00915 2/20 0.56
CA12 O43570 1/20 0.56
CA4 P22748 1/20 0.56
SIGMAR1 Q99720 4/20 0.53
KDM4E B2RXH2 1/20 0.51
ALDH1A1 P00352 1/20 0.51
FDPS P14324 1/20 0.51
OPRM1 P35372 2/20 0.51
OPRD1 P41143 2/20 0.51
OPRK1 P41145 2/20 0.51
CA5A P35218 1/20 0.50
CA7 P43166 1/20 0.50
CA5B Q9Y2D0 1/20 0.50
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
HTT P42858 1/20 0.49
BCHE P06276 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9136277 0.87 TAAR1 (0.66) OPRM1OPRD1OPRK1GAA
SCHEMBL3824789 0.84 SIGMAR1 (0.55) CA2CA1CA12CA4SIGMAR1
SCHEMBL5020719 0.83 MAOB (0.55) CA2ALDH1A1GAAHPGD
SCHEMBL5020711 0.83 CA2 (0.55) CA2GAAHPGD
SCHEMBL25676 0.82 CES1 (0.64) CA2ALDH1A1
SCHEMBL18798798 0.81 MAPT (0.58) CA2GAAHPGD
SCHEMBL4344215 0.81 TAAR1 (0.54) CA2CA1CA12CA4SIGMAR1
SCHEMBL379647 0.81 SIGMAR1 (0.65) SIGMAR1OPRK1
Hydrochloric Acid SCHEMBL1621316 0.80 CES1 (0.61) CA2ALDH1A1
Hydrochloric Acid SCHEMBL3651517 0.80 CES1 (0.61) CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105541750-B A kind of preparation method of Mirabegron analysis of control product 湖南方盛制药股份有限公司 2018-01-05 CN disclosed