SCHEMBL2820524

SCHEMBL2820524

Cc1c(C(C)C)nc2cc(F)c(F)cc2c1O

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GCGR P47871 3/20 0.33
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
KDM1A O60341 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2819742 0.79 KDM1A (0.33) KDM1A
SCHEMBL2823274 0.74 DHODH (0.31)
SCHEMBL2821974 0.73 MEN1 (0.35) CYP11B1CYP11B2KDM1A
SCHEMBL2826463 0.71 GCGR (0.35) GCGR
SCHEMBL2822997 0.70 L3MBTL1 (0.33) CYP11B1CYP11B2
SCHEMBL2712340 0.67 MAPT (0.33)
SCHEMBL2821680 0.67 PTGS2 (0.36)
SCHEMBL2820687 0.65 AR (0.33) CYP11B1CYP11B2
SCHEMBL28446607 0.65 MEN1 (0.33)
SCHEMBL20857341 0.65 IRAK4 (0.39) CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1386914-B1 HALOGENATED QUINOLINE DERIVATIVES AND ECTOPARASITE CONTROLLERS MEIJI SEIKA KAISHA (JP) 2010-10-27 EP disclosed
CN-1310889-C Halogen-substituted quinoline derivatives and ectoparasite control agent MEIJI SEIKA KAISHA (JP) 2007-04-18 CN disclosed
US-7022855-B2 Halogen-substituted quinoline derivatives and ectoparasite control agent MEIJI SEIKA KAISHA, LTD. (JP) 2006-04-04 US disclosed
CN-1688193-A Mixed compositions for controlling parasitic insects MEIJI SEIKA KAISHA (JP) 2005-10-26 CN disclosed
EP-1559321-A1 MIXED COMPOSITIONS FOR CONTROLLING PARASITIC INSECTS MEIJI SEIKA KAISHA LTD. (JP) 2005-08-03 EP disclosed
US-20040087618-A1 Halogen-substituted quinoline derivatives and ectoparasite control agent MEIJI SEIKA KAISHA, LTD. (JP) 2004-05-06 US disclosed
US-20040077602-A1 Mixture composition for controlling ectoparasites MEIJI SEIKA KAISHA, LTD. (JP) 2004-04-22 US disclosed
EP-1386914-A1 HALOGENATED QUINOLINE DERIVATIVES AND ECTOPARASITE CONTROLLERS MEIJI SEIKA KAISHA LTD. (JP) 2004-02-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040087618-A1 Halogen-substituted quinoline derivatives and ectoparasite control agent ATL3, RABL3, RAB5C GCGR 2014/4885CYP11B1 2551/4885CYP11B2 2349/4885
US-20040077602-A1 Mixture composition for controlling ectoparasites SF3A3, PEX3, HCN3 GCGR 1360/4885CYP11B1 537/4885CYP11B2 446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.