Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | P2RY10 | O00398 | 4/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 4/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13583338 | 1.00 | ALDH1A1 (0.41) | ALDH1A1SLC7A5LMNAP2RY10GPR174 | |
| SCHEMBL16124705 | 0.89 | LMNA (0.50) | ALDH1A1SLC7A5LMNAP2RY10GPR174 | |
| SCHEMBL31207053 | 0.86 | LMNA (0.61) | ALDH1A1LMNAP2RY10GPR174MAPT | |
| SCHEMBL359908 | 0.86 | LMNA (0.61) | ALDH1A1LMNAP2RY10GPR174MAPT | |
| SCHEMBL27825794 | 0.86 | LMNA (0.61) | ALDH1A1LMNAP2RY10GPR174MAPT | |
| SCHEMBL31207140 | 0.86 | LMNA (0.61) | ALDH1A1LMNAP2RY10GPR174MAPT | |
| SCHEMBL359909 | 0.86 | LMNA (0.61) | ALDH1A1LMNAP2RY10GPR174MAPT | |
| SCHEMBL16124704 | 0.86 | LMNA (0.61) | ALDH1A1LMNAP2RY10GPR174MAPT | |
| SCHEMBL27825787 | 0.86 | LMNA (0.61) | ALDH1A1LMNAP2RY10GPR174MAPT | |
| SCHEMBL8982550 | 0.85 | SLC7A5 (0.41) | SLC7A5LMNAP2RY10GPR174SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090669-B2 | Short fatty acid tail polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS LTD. (FI) | 2015-07-28 | — | — | US | claimed |
| US-20140142030-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2014-05-22 | — | — | US | claimed |
| US-8642535-B2 | Short fatty acid tail polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS LTD. (FI) | 2014-02-04 | — | — | US | claimed |
| US-20120283176-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2012-11-08 | — | — | US | claimed |
| US-20240207213-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS WITH ORAL SYSTEMICALLY BIOAVAILABLE BUTYRATE CONJUGATES | THE UNIVERSITY OF CHICAGO | 2024-06-27 | — | — | US | disclosed |
| EP-4326232-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS WITH ORAL SYSTEMICALLY BIOAVAILABLE BUTYRATE CONJUGATES | The University of Chicago (US) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022226482-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS WITH ORAL SYSTEMICALLY BIOAVAILABLE BUTYRATE CONJUGATES | THE UNIVERSITY OF CHICAGO (US) | 2022-10-27 | — | — | WO | disclosed |
| US-20200188476-A1 | ANTI-MICROBIAL AGENT-POLYMER CONJUGATES AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2020-06-18 | — | — | US | disclosed |
| WO-2018195078-A1 | ANTI-MICROBIAL AGENT-POLYMER CONJUGATES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-10-25 | — | — | WO | disclosed |
| EP-3263586-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | Northern Antibiotics Oy (FI) | 2018-01-03 | — | — | EP | disclosed |
| EP-2242765-B1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS OY (FI) | 2017-01-11 | — | — | EP | disclosed |
| EP-3078672-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | Northern Antibiotics Oy (FI) | 2016-10-12 | — | — | EP | disclosed |
| US-7807637-B2 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY (FI) | 2010-10-05 | — | — | US | disclosed |
| US-20090239792-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-09-24 | — | — | US | disclosed |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-08-27 | — | — | US | disclosed |
| WO-2009098357-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS OY (FI) | 2009-08-13 | — | — | WO | disclosed |
| CN-101501063-A | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY (FI) | 2009-08-05 | — | — | CN | disclosed |
| EP-2057185-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | Northern Antibiotics Oy (FI) | 2009-05-13 | — | — | EP | disclosed |
| US-20080287345-A1 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY (FI) | 2008-11-20 | — | — | US | disclosed |
| WO-2008017734-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS OY (FI) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239792-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | TLR5, TLR3, TLR2 | ALDH1A1 4688/4885SLC7A5 410/4885LMNA 1825/4885 |
| US-20240207213-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS WITH ORAL SYSTEMICALLY BIOAVAILABLE BUTYRATE CONJUGATES | HBB, SI, FABP2 | ALDH1A1 493/4885SLC7A5 1199/4885LMNA 2625/4885 |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | C5, C9, C3AR1 | ALDH1A1 4876/4885SLC7A5 242/4885LMNA 3052/4885 |
| US-20200188476-A1 | ANTI-MICROBIAL AGENT-POLYMER CONJUGATES AND METHODS OF USE THEREOF | DDOST, MGAM, MSN | ALDH1A1 4571/4885SLC7A5 1688/4885LMNA 4287/4885 |
| US-20140142030-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | VIP, ELOVL5, TLR5 | ALDH1A1 4708/4885SLC7A5 178/4885LMNA 1420/4885 |
| US-20120283176-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | ELOVL5, TLR5, VIP | ALDH1A1 4715/4885SLC7A5 179/4885LMNA 1402/4885 |
| US-20080287345-A1 | Polymyxin derivatives and uses thereof | C9, C5, C3AR1 | ALDH1A1 4876/4885SLC7A5 224/4885LMNA 3194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.