Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Carbazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | GPR3 | P46089 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbazole SCHEMBL573588 | 0.88 | ALDH1A1 (0.70) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL10650068 | 0.83 | ALDH1A1 (0.70) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL742559 | 0.83 | ALDH1A1 (0.70) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Acridone SCHEMBL28404154 | 0.80 | ALDH1A1 (0.75) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL16345387 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL28852407 | 0.79 | ALDH1A1 (0.78) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL7149138 | 0.77 | ALDH1A1 (0.74) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL28048441 | 0.76 | ALDH1A1 (0.82) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL28689618 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HSD17B10GPR3KDM4EGAA | |
| Carbazole SCHEMBL3924065 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HSD17B10GPR3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107868033-A | A kind of preparation method of phenylalanine class compound | 深圳微芯生物科技有限责任公司 | 2018-04-03 | — | — | CN | disclosed |