Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7193959 | 0.96 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL28216031 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL975 | 0.88 | — | — | |
| Tromethamine SCHEMBL17484 | 0.88 | MEN1 (1.00) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL3696191 | 0.88 | — | — | |
| Tromethamine SCHEMBL1019777 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL571834 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL11744295 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL9644059 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL7510306 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401567-B1 | UNIMOLECULAR POLYMERIC MICELLES WITH AN IONIZABLE INNER CORE | LABOPHARM INC (CA) | 2004-12-22 | — | — | EP | disclosed |
| EP-1401567-A1 | UNIMOLECULAR POLYMERIC MICELLES WITH AN IONIZABLE INNER CORE | LABOPHARM INC. (CA) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100529-A1 | UNIMOLECULAR POLYMERIC MICELLES WITH AN IONIZABLE INNER CORE | LABOPHARM, INC. (CA) | 2002-12-19 | — | — | WO | disclosed |