SCHEMBL28220176

SCHEMBL28220176

COc1ccc(Cc2ccccc2NC(C)=O)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.58
L3MBTL1 Q9Y468 1/20 0.52
SAE1 Q9UBE0 1/20 0.51
UBA2 Q9UBT2 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
KMT2A Q03164 2/20 0.50
POLB P06746 1/20 0.50
GRK2 P25098 1/20 0.50
PPARG P37231 1/20 0.50
CTDSP1 Q9GZU7 1/20 0.50
NR2E3 Q9Y5X4 1/20 0.50
NCOR2 Q9Y618 1/20 0.50
MTNR1A P48039 1/20 0.49
MTNR1B P49286 1/20 0.49
F10 P00742 1/20 0.49
LTA4H P09960 1/20 0.49
GAA P10253 1/20 0.48
TSHR P16473 1/20 0.48
HPGD P15428 1/20 0.47
KDM4E B2RXH2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4681910 0.88 ALDH1A1 (0.62) ALDH1A1L3MBTL1SAE1UBA2SMN1; SMN2
SCHEMBL10690936 0.86 ALDH1A1 (0.56) ALDH1A1L3MBTL1SAE1UBA2SMN1; SMN2
SCHEMBL7522410 0.84 L3MBTL1 (0.71) ALDH1A1L3MBTL1SMN1; SMN2POLBTSHR
SCHEMBL10693527 0.84 SMN1; SMN2 (0.59) ALDH1A1L3MBTL1SMN1; SMN2KMT2APOLB
SCHEMBL6096285 0.83 L3MBTL1 (0.56) ALDH1A1L3MBTL1SMN1; SMN2KMT2APOLB
SCHEMBL9167530 0.83 L3MBTL1 (0.56) ALDH1A1L3MBTL1SMN1; SMN2KMT2ATSHR
SCHEMBL6097904 0.82 L3MBTL1 (0.55) ALDH1A1L3MBTL1SMN1; SMN2POLBTSHR
SCHEMBL7484877 0.79 TSHR (0.58) ALDH1A1L3MBTL1KMT2APOLBGRK2
SCHEMBL6097282 0.77 CYP19A1 (0.51) ALDH1A1L3MBTL1SMN1; SMN2KMT2APOLB
SCHEMBL28251912 0.77 LTA4H (0.72) L3MBTL1SMN1; SMN2KMT2ALTA4HMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108324719-A Adjacent toluidino acetylamino anisyl benzo-aza * bases quinazoline compounds are preparing the application in treating uterine neck cancer drug 浙江工业大学 2018-07-27 CN disclosed
CN-108125961-A Morpholinyl acetylamino anisyl benzo-aza * bases quinazoline compounds are preparing the application in treating leukemia medicament 浙江工业大学 2018-06-08 CN disclosed