Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | GRN | P28799 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825380 | 0.82 | SMN1; SMN2 (0.46) | ALDH1A1ALOX15LMNANPSR1KDM4E | |
| SCHEMBL25269324 | 0.80 | ALDH1A1 (0.41) | ALDH1A1ALOX15LMNANPSR1KDM4E | |
| SCHEMBL14038235 | 0.80 | ALOX15 (0.55) | ALDH1A1ALOX15LMNANPSR1KDM4E | |
| SCHEMBL2825323 | 0.79 | ALOX15 (0.38) | ALDH1A1ALOX15LMNANPSR1KDM4E | |
| SCHEMBL25269986 | 0.79 | ALDH1A1 (0.40) | ALDH1A1ALOX15LMNANPSR1KDM4E | |
| SCHEMBL2825283 | 0.78 | ALDH1A1 (0.40) | ALDH1A1ALOX15LMNANPSR1HSD17B10 | |
| SCHEMBL8654020 | 0.77 | ALOX15 (0.57) | ALDH1A1ALOX15LMNANPSR1KDM4E | |
| SCHEMBL14012153 | 0.76 | LMNA (0.38) | ALDH1A1ALOX15LMNANPSR1HSD17B10 | |
| SCHEMBL2825362 | 0.76 | ALDH1A1 (0.44) | ALDH1A1ALOX15LMNANPSR1KDM4E | |
| SCHEMBL2825371 | 0.72 | HRH3 (0.45) | ALDH1A1KDM4EL3MBTL1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1989139-B | Benzothiazole derivatives | HOFFMANN LA ROCHE | 2010-05-12 | — | — | CN | claimed |
| EP-1773827-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-02-17 | — | — | EP | claimed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | claimed |
| CN-1989139-A | Benzothiazole derivatives | HOFFMANN LA ROCHE (CH) | 2007-06-27 | — | — | CN | claimed |
| EP-1773827-A1 | BENZOTHIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-18 | — | — | EP | claimed |
| US-20060019949-A1 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2006-01-26 | — | — | US | claimed |
| WO-2006008041-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-26 | — | — | WO | claimed |
| CN-1989139-B | Benzothiazole derivatives | HOFFMANN LA ROCHE | 2010-05-12 | — | — | CN | disclosed |
| EP-1773827-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-02-17 | — | — | EP | disclosed |
| EP-1773827-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-02-17 | — | — | EP | disclosed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| CN-1989139-A | Benzothiazole derivatives | HOFFMANN LA ROCHE (CH) | 2007-06-27 | — | — | CN | disclosed |
| EP-1773827-A1 | BENZOTHIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-18 | — | — | EP | disclosed |
| US-20060019949-A1 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2006-01-26 | — | — | US | disclosed |
| WO-2006008041-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-26 | — | — | WO | disclosed |
| WO-2006008041-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019949-A1 | Benzothiazole derivatives | CNR2, CNR1, CHRNA2 | ALDH1A1 146/4885ALOX15 625/4885LMNA 3704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.