Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827377 | 0.88 | SMN1; SMN2 (0.41) | ALOX15ALDH1A1LMNANPSR1PDCD1 | |
| SCHEMBL2823208 | 0.83 | ALDH1A1 (0.37) | ALOX15ALDH1A1LMNANPSR1KAT2B | |
| SCHEMBL2823116 | 0.79 | ALDH1A1 (0.38) | ALOX15ALDH1A1LMNANPSR1F10 | |
| SCHEMBL2825362 | 0.76 | ALDH1A1 (0.44) | ALOX15ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL25269324 | 0.71 | ALDH1A1 (0.41) | ALOX15ALDH1A1LMNANPSR1KDM4E | |
| SCHEMBL14038235 | 0.71 | ALOX15 (0.55) | ALOX15ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL2825380 | 0.70 | SMN1; SMN2 (0.46) | ALOX15ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL25269986 | 0.70 | ALDH1A1 (0.40) | ALOX15ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL8654020 | 0.68 | ALOX15 (0.57) | ALOX15ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL14012153 | 0.67 | LMNA (0.38) | ALOX15ALDH1A1LMNANPSR1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773827-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-02-17 | — | — | EP | claimed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | claimed |
| EP-1773827-A1 | BENZOTHIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-18 | — | — | EP | claimed |
| US-20060019949-A1 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2006-01-26 | — | — | US | claimed |
| WO-2006008041-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-26 | — | — | WO | claimed |
| EP-1773827-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-02-17 | — | — | EP | disclosed |
| EP-1773827-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-02-17 | — | — | EP | disclosed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371749-B2 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| EP-1773827-A1 | BENZOTHIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-18 | — | — | EP | disclosed |
| US-20060019949-A1 | Benzothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2006-01-26 | — | — | US | disclosed |
| WO-2006008041-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-26 | — | — | WO | disclosed |
| WO-2006008041-A1 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019949-A1 | Benzothiazole derivatives | CNR2, CNR1, CHRNA2 | ALOX15 625/4885ALDH1A1 146/4885LMNA 3704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.