Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2832391 | 0.91 | GRM5 (0.38) | METMAPTL3MBTL1KDM1AMAOB | |
| SCHEMBL2830226 | 0.87 | MET (0.39) | METMAPTL3MBTL1 | |
| SCHEMBL2829461 | 0.85 | GRM5 (0.48) | KDM1AMAOBRCOR1FAAHALDH1A1 | |
| SCHEMBL2828971 | 0.80 | NPC1 (0.37) | KDM1AMAOBRCOR1ALDH1A1MAPK1 | |
| SCHEMBL2826716 | 0.79 | GRM5 (0.50) | MAPTPOLBMEN1NPC1RAB9A | |
| SCHEMBL2832249 | 0.79 | MAPT (0.37) | MAPTALDH1A1MAPK1MEN1NPC1 | |
| SCHEMBL2830759 | 0.79 | SMARCA2 (0.43) | POLBNPC1RAB9AKMT2AGRM5 | |
| SCHEMBL2826556 | 0.78 | GRM5 (0.39) | MAPTL3MBTL1POLBMEN1NPC1 | |
| SCHEMBL2830402 | 0.77 | MAPT (0.45) | MAPTL3MBTL1ALDH1A1MAPK1POLB | |
| SCHEMBL2829130 | 0.77 | GRM5 (0.51) | MAPTL3MBTL1POLBMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |