Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824749 | 0.91 | MET (0.42) | GRM5MAPTL3MBTL1METKDM1A | |
| SCHEMBL2829461 | 0.82 | GRM5 (0.48) | GRM5SIRT2KDM1AMAOBRCOR1 | |
| SCHEMBL2831334 | 0.81 | GRM5 (0.54) | GRM5CYP3A4 | |
| SCHEMBL2829033 | 0.80 | GRM5 (0.44) | GRM5CYP3A4 | |
| SCHEMBL2830226 | 0.79 | MET (0.39) | MAPTL3MBTL1METBRAF | |
| SCHEMBL2832204 | 0.78 | GRM5 (0.56) | GRM5CYP3A4 | |
| SCHEMBL2828971 | 0.77 | NPC1 (0.37) | GRM5KDM1AMAOBRCOR1ALDH1A1 | |
| SCHEMBL2830056 | 0.77 | GRM5 (0.39) | GRM5MAPK1 | |
| SCHEMBL2831104 | 0.76 | GRM5 (0.37) | GRM5L3MBTL1 | |
| SCHEMBL2829064 | 0.76 | GRM5 (0.41) | GRM5MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |